{"id":17,"date":"2015-03-26T16:10:28","date_gmt":"2015-03-26T07:10:28","guid":{"rendered":"http:\/\/synapse.dept.med.gunma-u.ac.jp\/index_sample.php\/?page_id=17"},"modified":"2023-07-14T11:43:16","modified_gmt":"2023-07-14T02:43:16","slug":"research","status":"publish","type":"page","link":"https:\/\/synapse.dept.med.gunma-u.ac.jp\/?page_id=17","title":{"rendered":"Research"},"content":{"rendered":"

\u7814\u7a76\u5185\u5bb9<\/h2>\n

\u65b0\u898f\u30a2\u30c7\u30ce\u968f\u4f34\u30a6\u30a4\u30eb\u30b9(AAV)\u30d9\u30af\u30bf\u30fc\u306e\u958b\u767a\u3001\u53ca\u3073AAV\u30d9\u30af\u30bf\u30fc\u3092\u99c6\u4f7f\u3057\u305f\u8133\u795e\u7d4c\u7cfb\u306e\u751f\u7406\u75c5\u614b\u7814\u7a76\u3092\u9042\u884c\u3057\u3066\u3044\u307e\u3059\u3002<\/h4>\n

1. \u76ee\u899a\u307e\u3057\u3044\u767a\u5c55\u3092\u9042\u3052\u308bAAV\u30d9\u30af\u30bf\u30fc<\/h3>\n

2020\u5e74\u524d\u534a\u306b\u4f5c\u3063\u305f\u30b0\u30e9\u30d5\u3067\u3059\u304c\u3001\u30a6\u30a4\u30eb\u30b9\u30d9\u30af\u30bf\u30fc\u306e\u8ad6\u6587\u306f1980\u5e74\u3054\u308d\u304b\u3089\u4e00\u8cab\u3057\u3066\u5897\u52a0\u3057\u3066\u3044\u307e\u3059\u3002\u305f\u3060\u8a73\u3057\u304f\u307f\u308b\u3068\u3053\u306e\u9593\u3001\u4f7f\u7528\u3055\u308c\u308b\u30a6\u30a4\u30eb\u30b9\u30d9\u30af\u30bf\u30fc\u306e\u7a2e\u985e\u306e\u79fb\u308a\u5909\u308f\u3063\u3066\u3044\u308b\u306e\u304c\u308f\u304b\u308a\u307e\u3059\u3002\u30a2\u30c7\u30ce\u30a6\u30a4\u30eb\u30b9\u30d9\u30af\u30bf\u30fc\u306e\u8ad6\u6587\u306f1990\u5e74\u4ee3\u3088\u308a\u6025\u6fc0\u306b\u5897\u3048\u3066\u3044\u307e\u3059\u304c\u30012004\u5e74\u3054\u308d\u3092\u30d4\u30fc\u30af\u306b\u6e1b\u5c11\u3001\u30ec\u30f3\u30c1\u30a6\u30a4\u30eb\u30b9\u30d9\u30af\u30bf\u30fc\u306e\u8ad6\u6587\u306f1986\u5e74\u304b\u3089\u30b3\u30f3\u30b9\u30bf\u30f3\u30c8\u306b\u5897\u52a0\u3057\u30012013\u5e74\u3054\u308d\u304b\u3089\u6e1b\u5c11\u3001AAV\u30d9\u30af\u30bf\u30fc\u306e\u8ad6\u6587\u306f1994\u5e74\u3054\u308d\u304b\u3089\u5897\u3048\u59cb\u3081\u30012014\u5e74\u3054\u308d\u304b\u3089\u5897\u52a0\u304c\u52a0\u901f\u3057\u3066\u3044\u308b\u306e\u304c\u308f\u304b\u308a\u307e\u3059\u30022023\u5e746\u6708\u73fe\u5728\u30013\u5e74\u3076\u308a\u306bAAV\u306e\u8ad6\u6587\u3092\u691c\u7d22\u3059\u308b\u3068\u3001\u5897\u52a0\u30b9\u30d4\u30fc\u30c9\u304c\u52a0\u901f\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002AAV\u30d9\u30af\u30bf\u30fc\u3092\u7528\u3044\u305f\u907a\u4f1d\u5b50\u5c0e\u5165\u306f\u751f\u547d\u79d1\u5b66\u7814\u7a76\u304b\u3089\u30d2\u30c8\u3078\u306e\u81e8\u5e8a\u5fdc\u7528\u307e\u3067\u76ee\u899a\u307e\u3057\u3044\u767a\u5c55\u3092\u9042\u3052\u3066\u3044\u307e\u3059\u3002<\/p>\n

\"\"<\/a><\/p>\n

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\"\"<\/a><\/p>\n

 <\/p>\n

2. \u8133\u306e\u7d30\u80de\u7a2e\u7279\u7570\u7684AAV\u30d9\u30af\u30bf\u30fc\u306e\u958b\u767a<\/h3>\n

\u8133\u5185\u306b\u306f\u30cb\u30e5\u30fc\u30ed\u30f3\u3068\u30b0\u30ea\u30a2\u7d30\u80de\u304c\u3042\u308a\u3001\u30cb\u30e5\u30fc\u30ed\u30f3\u306b\u306f\u8208\u596e\u6027\u3068\u6291\u5236\u6027\u3001\u30b0\u30ea\u30a2\u7d30\u80de\u306b\u306f\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u3001\u30aa\u30ea\u30b4\u30c7\u30f3\u30c9\u30ed\u30b5\u30a4\u30c8\u3001\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306a\u3069\u304c\u3042\u308a\u307e\u3059\u3002\u6211\u3005\u306f\u3053\u308c\u307e\u3067\u306b\u3001AAV\u3067\u4f7f\u3048\u308b\u69d8\u3005\u306a\u7d30\u80de\u7a2e\u7279\u7570\u7684\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u3092\u958b\u767a\u3057\u3001\u307b\u307c\u5168\u3066\u306e\u7d30\u80de\u7a2e\u306b\u304a\u3044\u3066\u7279\u7570\u7684\u306a\u907a\u4f1d\u5b50\u767a\u73fe\u304c\u53ef\u80fd\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u3044\u304b\u306b\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u3068\u5c0f\u8133\u30d7\u30eb\u30ad\u30f3\u30a8\u7d30\u80de\u306e\u4f8b\u3092\u793a\u3057\u307e\u3059\u3002<\/p>\n

\"\"\u00a0 \u00a0 <\/a>\"\". \u00a0\u00a0 <\/a>\"\"<\/a><\/p>\n

Okada Y<\/strong>,\u00a0Hosoi N<\/strong>,\u00a0Matsuzaki Y<\/strong>,\u00a0Fukai Y<\/strong>,\u00a0Hiraga A<\/strong>, Nakai J,\u00a0Nitta K<\/strong>,\u00a0Shinohara Y<\/strong>,\u00a0Konno A<\/strong>,\u00a0Hirai H<\/strong>.
\nDevelopment of microglia-targeting adeno-associated viral vectors as tools to study microglial behavior in vivo.<\/a>
\nCommun Biol.\u00a0<\/span>2022 Nov 11;5(1):1224. doi: 10.1038\/s42003-022-04200-3.<\/p>\n

Nitta K<\/strong>,\u00a0Matsuzaki<\/strong>\u00a0Y<\/strong>,\u00a0Konno A<\/strong>,\u00a0Hirai H<\/strong>
\nMinimal Purkinje Cell-Specific PCP2\/L7 Promoter Virally Available for Rodents and Non-human Primates.<\/a>
\nMol Ther Methods Clin Dev.\u00a0<\/span>2017 Jul 27;6:159-170.<\/p>\n

<\/section>\n

\uff13. \u9759\u8108\u5185\u6295\u4e0e\u3067\u8840\u6db2\u8133\u95a2\u9580(BBB)\u3092\u901a\u308a\u629c\u3051\u3001\u5168\u8133\u306b\u907a\u4f1d\u5b50\u5c0e\u5165\u3067\u304d\u308bAAV\u30d9\u30af\u30bf\u30fc\u306e\u958b\u767a<\/h3>\n

AAV9\u30ab\u30d7\u30b7\u30c9\u30d9\u30af\u30bf\u30fc\u306f\u9759\u8108\u6295\u4e0e\u3059\u308b\u3068\u8133\u5185\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u3092\u308f\u305a\u304b\u306b\u900f\u904e\u3059\u308b\u306e\u3067\u3059\u304c\u3001AAV9\u30ab\u30d7\u30b7\u30c9\u306e\u5909\u7570\u4f53\u3067\u3042\u308bPHP.B\u3084PHP.eB\u306f\u3001\u9065\u306b\u52b9\u7387\u7684\u306b\u8840\u7ba1\u5185\u76ae\u306b\u53d6\u308a\u8fbc\u307e\u308c\u3066\u901a\u308a\u629c\u3051\u307e\u3059\u3002\u4e00\u65b9\u3001AAV2\u306f\u308f\u305a\u304b\u306b\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306b\u53d6\u308a\u8fbc\u307e\u308c\u305f\u306e\u3061\u3001\u901a\u308a\u629c\u3051\u305a\u306b\u6838\u306b\u904b\u3070\u308c\u3066\u8840\u7ba1\u5185\u76ae\u3067\u907a\u4f1d\u5b50\u767a\u73fe\u3057\u307e\u3059\u3002BR1\u306fAAV2\u306e\u5909\u7570\u4f53\u3067\u3001\u91ce\u751f\u578b\u306eAAV2\u3088\u308a\u9855\u8457\u306b\u8840\u7ba1\u5185\u76ae\u306b\u53d6\u308a\u8fbc\u307e\u308c\u3001\u305d\u306e\u5f8c\u3001AAV\uff12\u3068\u540c\u69d8\u3001\u901a\u308a\u629c\u3051\u305a\u306b\u5185\u76ae\u7d30\u80de\u3067\u907a\u4f1d\u5b50\u767a\u73fe\u3057\u307e\u3059\u3002\u3059\u306a\u308f\u3061\u3001\u3053\u308c\u3089\u306f\u8133\u5185\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306b\u52b9\u7387\u7684\u306b\u53d6\u308a\u8fbc\u307e\u308c\u308b\u6027\u8cea\u3092\u7372\u5f97\u3057\u305f\u5909\u7570\u4f53\u3067\u3042\u308a\u3001\u7d30\u80de\u5185\u306b\u5165\u3063\u305f\u5f8c\u306f\u3001\u305d\u308c\u305e\u308c\u306e\u6027\u8cea\u3067\u3042\u308btranscytosis\u3001transduction\u3092\u8d77\u3053\u3059\u3068\u8a00\u3048\u307e\u3059\u3002<\/p>\n

\"\"<\/a><\/p>\n

BR1\u306fAAV2\u30ab\u30d7\u30b7\u30c9\u306eVariable region VIII\u306b\uff19\u500b\u306e\u30a2\u30df\u30ce\u9178\u304c\u633f\u5165\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u3053\u308c\u306b\u52a0\u3048\u3066587\u756a\u76ee\u306e\u30a2\u30b9\u30d1\u30e9\u30ae\u30f3\u304c\u30b0\u30eb\u30bf\u30df\u30f3\u306b\u5909\u308f\u3063\u3066\u3044\u307e\u3059\u3002\u79c1\u9054\u306f\u3001\u30aa\u30ea\u30b8\u30ca\u30eb\u8ad6\u6587\u3068\u306f\u7570\u306a\u308b\u65b9\u6cd5\u3067BR1\u3092\u4f5c\u88fd\u3057\u305f\u306e\u3067\u3001587\u756a\u76ee\u306eN\u304c\u5909\u308f\u3089\u305a\u306bN\u306e\u307e\u307e\u3067\u3057\u305f\u3002\u3053\u308c\u3092BR1N\u3068\u540d\u4ed8\u3051\u307e\u3057\u305f\u3002\u7279\u306bN\u306e\u307e\u307e\u3067\u3082\u554f\u984c\u306f\u306a\u3044\u3060\u308d\u3046\u3068\u8003\u3048BR1N\u3092\u3001\u30de\u30a6\u30b9\u306b\u9759\u6ce8\u3057\u305f\u3068\u3053\u308d\u3001BBB\u3092\u901a\u308a\u629c\u3051\u3066\u30cb\u30e5\u30fc\u30ed\u30f3\u306b\u907a\u4f1d\u5b50\u767a\u73fe\u3059\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n

\u3059\u306a\u308f\u3061\u30ab\u30d7\u30b7\u30c9\u306e587\u756a\u76ee\u306e\u30a2\u30df\u30ce\u9178\u304c\u30b0\u30eb\u30bf\u30df\u30f3\u3067\u3042\u308bBR1\u306f\u8840\u6db2\u8133\u95a2\u9580\u3092\u901a\u308a\u629c\u3051\u305a\u3001\u8840\u7ba1\u5185\u76ae\u306b\u907a\u4f1d\u5b50\u767a\u73fe\u3059\u308b\u306e\u306b\u5bfe\u3057\u3001587\u756a\u76ee\u306e\u30a2\u30df\u30ce\u9178\u304c\u30a2\u30b9\u30d1\u30e9\u30ae\u30f3\u3067\u3042\u308bBR1N\u306f\u901a\u308a\u629c\u3051\u3066\u30cb\u30e5\u30fc\u30ed\u30f3\u3067\u907a\u4f1d\u5b50\u767a\u73fe\u3059\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n

\"\". \u00a0\u00a0\u00a0 <\/a>\"\"<\/a><\/p>\n

Kawabata H, Konno A, Matsuzaki Y, Hirai H.<\/strong>
\nA blood-brain barrier-penetrating AAV2 mutant created by a brain microvasculature endothelial cell-targeted AAV2 variant.<\/a>
\nMol Ther Methods Clin Dev.\u00a0<\/span>2023 Mar 2;29:81-92. doi: 10.1016\/j.omtm.2023.02.016. eCollection 2023 Jun 8.<\/p>\n

\u3053\u308c\u3089\u306e\u7d50\u679c\u304b\u3089\u3001AAV9\u3060\u3051\u3067\u306a\u304f\u69d8\u3005\u306aAAV\u8840\u6e05\u578b\u304b\u3089BBB\u900f\u904e\u578b\u30ab\u30d7\u30b7\u30c9\u5909\u7570\u4f53\u304c\u4f5c\u88fd\u3067\u304d\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u7814\u7a76\u306b\u52a0\u3048\u3066\u3001\u73fe\u5728\u3001\u30de\u30fc\u30e2\u30bb\u30c3\u30c8\u306e\u8840\u6db2\u8133\u95a2\u9580\u3092\u901a\u308a\u629c\u3051\u308bAAV\u30ab\u30d7\u30b7\u30c9\u5909\u7570\u4f53\u306e\u958b\u767a\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u65e5\u672c\u8a9e\u306e\u7dcf\u8aac\u306a\u3069<\/strong><\/h4>\n
    \n
  • \u5e73\u4e95\u5b8f\u548c. \u30a6\u30a4\u30eb\u30b9\u30d9\u30af\u30bf\u30fc\u9759\u8108\u6295\u4e0e\u306b\u3088\u308b\u810a\u9ac4\u5c0f\u8133\u5909\u6027\u75c7\u52d5\u7269\u30e2\u30c7\u30eb\u306e\u4f5c\u51fa. Clinical Neuroscience<\/i><\/b>. 37\u5dfb8\u53f7\uff08\u5370\u5237\u4e2d\uff09<\/li>\n
  • \u4eca\u91ce\u6b69, \u5e73\u4e95\u5b8f\u548c. \u30a6\u30a4\u30eb\u30b9\u30d9\u30af\u30bf\u30fc\u306e\u9759\u8108\u6295\u4e0e\u306b\u3088\u308b\u30de\u30a6\u30b9\u8133\u5168\u57df\u3078\u306e\u907a\u4f1d\u5b50\u5c0e\u5165. \u5b9f\u9a13\u533b\u5b66<\/b>. 2019; 37(4): 581-587.<\/li>\n
  • \u5e73\u4e95\u5b8f\u548c. \u907a\u4f1d\u5b50\u5c0e\u5165. \u8133\u79d1\u5b66\u8f9e\u5178<\/b>; 2018. doi:10.14931\/bsd.7623<\/li>\n
  • \u5e73\u4e95\u5b8f\u548c. \u30a6\u30a4\u30eb\u30b9\u30d9\u30af\u30bf\u30fc. \u8133\u79d1\u5b66\u8f9e\u5178<\/b>; 2018. doi:10.14931\/bsd.7632<\/li>\n
  • \u5e73\u4e95\u5b8f\u548c. \u30d0\u30af\u30ed\u30d5\u30a7\u30f3\u3067\u810a\u9ac4\u5c0f\u8133\u5931\u8abf\u75c7\uff11\u578b\u306e\u904b\u52d5\u5931\u8abf\u304c\u3088\u304f\u306a\u308b\u306e\u304b\uff1f\u5168\u56fd\u810a\u9ac4\u5c0f\u8133\u5909\u6027\u75c7\uff08SCD\uff09\u30fb\u591a\u7cfb\u7d71\u840e\u7e2e\u75c7\uff08MSA\uff09\u53cb\u306e\u4f1a\u30cb\u30e5\u30fc\u30b9<\/b>. No. 226: 10-14. 2017.04.25\u767a\u884c.<\/li>\n
  • \u5e73\u4e95\u5b8f\u548c. \u201c\u30cb\u30e5\u30fc\u30ed\u30f3\u7279\u7570\u7684\u30a8\u30ce\u30e9\u30fc\u30bc\uff08NSE\uff09\u201d\u306f\u708e\u75c7\u304c\u3042\u308b\u3068\u30cb\u30e5\u30fc\u30ed\u30f3\u3067\u306f\u306a\u304f\u30b0\u30ea\u30a2\u7d30\u80de\u3067\u7523\u751f\u3055\u308c\u308b. \u751f\u5316\u5b66<\/b>. 2017; 89(2): 241-243. doi:10.14952\/SEIKAGAKU.2017.890241<\/li>\n
  • \u5e73\u4e95\u5b8f\u548c. \u5c0f\u8133\u306e\u6a5f\u80fd\uff08\u57fa\u5e95\u6838\u3068\u5c0f\u8133\u2212\u305d\u306e\u76f8\u9055\u3068\u9023\u95a2\uff09Clinical Neuroscience<\/i><\/b>. Vol.35 (17\u5e7401\u6708\u53f7\uff09: 28-32. 2017.01.01\u767a\u884c.<\/li>\n
  • \u5e73\u4e95\u5b8f\u548c. \u810a\u9ac4\u5c0f\u8133\u5909\u6027\u75c7\u30fb\u591a\u7cfb\u7d71\u840e\u7e2e\u75c7\u306b\u5bfe\u3059\u308b\u5e79\u7d30\u80de\u7814\u7a76\u306e\u73fe\u72b6\u3000\u300e\u810a\u9ac4\u5c0f\u8133\u5909\u6027\u75c7\u30fb\u591a\u7cfb\u7d71\u840e\u7e2e\u75c7<\/b> Q&A 172<\/b>\u300f\u3000\u5e73\u621027\u5e743\u6708\u767a\u884c<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"

    \u7814\u7a76\u5185\u5bb9 \u65b0\u898f\u30a2\u30c7\u30ce\u968f\u4f34\u30a6\u30a4\u30eb\u30b9(AAV)\u30d9\u30af\u30bf\u30fc\u306e\u958b\u767a\u3001\u53ca\u3073AAV\u30d9\u30af\u30bf\u30fc\u3092\u99c6\u4f7f\u3057\u305f\u8133\u795e\u7d4c\u7cfb\u306e\u751f\u7406\u75c5\u614b\u7814\u7a76\u3092\u9042\u884c\u3057\u3066\u3044\u307e\u3059\u3002 1. \u76ee\u899a\u307e\u3057\u3044\u767a\u5c55\u3092\u9042\u3052\u308bAAV\u30d9\u30af\u30bf\u30fc 2020\u5e74\u524d\u534a\u306b\u4f5c\u3063\u305f\u30b0\u30e9\u30d5\u3067\u3059\u304c\u3001\u30a6\u30a4\u30eb\u30b9\u30d9\u30af […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":20,"comment_status":"open","ping_status":"open","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-17","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/synapse.dept.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/pages\/17","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/synapse.dept.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/synapse.dept.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/synapse.dept.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/synapse.dept.med.gunma-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=17"}],"version-history":[{"count":13,"href":"https:\/\/synapse.dept.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/pages\/17\/revisions"}],"predecessor-version":[{"id":2698,"href":"https:\/\/synapse.dept.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/pages\/17\/revisions\/2698"}],"wp:attachment":[{"href":"https:\/\/synapse.dept.med.gunma-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=17"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}