{"id":1018,"date":"2018-10-25T09:36:23","date_gmt":"2018-10-25T00:36:23","guid":{"rendered":"http:\/\/synapse.dept.med.gunma-u.ac.jp\/?p=1018"},"modified":"2018-10-25T09:36:23","modified_gmt":"2018-10-25T00:36:23","slug":"%e6%b8%a1%e9%82%8a%e5%b0%86%e7%a0%94%e7%a9%b6%e5%93%a1%e3%81%aesca3-mjd%e3%81%ab%e9%96%a2%e3%81%99%e3%82%8b%e8%ab%96%e6%96%87%e3%80%8cneurobiology-of-disease%e3%80%8d%e3%81%ab%e6%8e%b2%e8%bc%89","status":"publish","type":"post","link":"https:\/\/synapse.dept.med.gunma-u.ac.jp\/?p=1018","title":{"rendered":"\u6e21\u908a\u5c06\u7814\u7a76\u54e1\u306eSCA3\/MJD\u306b\u95a2\u3059\u308b\u8ad6\u6587\u300cNeurobiology of Disease\u300d\u306b\u63b2\u8f09\uff01"},"content":{"rendered":"<p>Neurobiol Dis. 2018 Oct 18. pii: S0969-9961(18)30730-7. doi: 10.1016\/j.nbd.2018.10.014. [Epub ahead of print]<br \/>\n<strong>Pharmacological enhancement of retinoid-related orphan receptor \u03b1 function mitigates spinocerebellar ataxia type 3 pathology.<\/strong><br \/>\nWatanave M, Hoshino C, Konno A, Fukuzaki Y, Matsuzaki Y, Ishitani T, Hirai H.<\/p>\n<p><a href=\"https:\/\/synapse.dept.med.gunma-u.ac.jp\/wp-content\/uploads\/2018\/10\/1-s2.0-S0969996118307307-ga4_lrg.jpg\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/synapse.dept.med.gunma-u.ac.jp\/wp-content\/uploads\/2018\/10\/1-s2.0-S0969996118307307-ga4_lrg.jpg\" alt=\"\" width=\"548\" height=\"295\" class=\"alignleft size-full wp-image-1028\" srcset=\"https:\/\/synapse.dept.med.gunma-u.ac.jp\/wp-content\/uploads\/2018\/10\/1-s2.0-S0969996118307307-ga4_lrg.jpg 548w, https:\/\/synapse.dept.med.gunma-u.ac.jp\/wp-content\/uploads\/2018\/10\/1-s2.0-S0969996118307307-ga4_lrg-300x161.jpg 300w\" sizes=\"auto, (max-width: 548px) 100vw, 548px\" \/><\/a><br \/>\n\u672c\u8ad6\u6587\u3067\u306f\u3001SCA3\/MJD\u306e\u539f\u56e0\u907a\u4f1d\u5b50\u3067\u3042\u308bATXN3\u3092\u30a6\u30a4\u30eb\u30b9\u30d9\u30af\u30bf\u30fc\u3067\u5c0f\u8133\u306b\u767a\u73fe\u3055\u305b\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u5c0f\u8133\u306e\u91cd\u8981\u306a\u30cb\u30e5\u30fc\u30ed\u30f3\u3067\u3042\u308b\u30d7\u30eb\u30ad\u30f3\u30a8\u7d30\u80de\u306b\u304a\u3044\u3066\u3001ROR\u03b1\uff08\u8ee2\u5199\u56e0\u5b50\uff09\u304c\u6e1b\u5c11\u3057\u3001\u6a39\u72b6\u7a81\u8d77\u306e\u5909\u6027\u3068\u30b7\u30ca\u30d7\u30b9\u6a5f\u80fd\u306e\u969c\u5bb3\u304c\u898b\u3089\u308c\u3001\u30de\u30a6\u30b9\u306f\u8457\u3057\u3044\u904b\u52d5\u5931\u8abf\u3092\u793a\u3057\u307e\u3057\u305f\uff08\u4e0a\uff09\u3002ATXN3\u767a\u73fe\u30a6\u30a4\u30eb\u30b9\u30d9\u30af\u30bf\u30fc\u3092\u5c0f\u8133\u306b\u6ce8\u5c04\u3057\u3066\uff11\u9031\u9593\u5f8c\u306b\u3001ROR\u03b1\u306e\u6a5f\u80fd\u3092\u5897\u5f37\u3059\u308bSR1078\u3068\u3044\u3046\u85ac\u5264\u3092\u8179\u8154\u306b\uff11\u5ea6\u3060\u3051\u6295\u4e0e\u3059\u308b\u3068\u3001\u30d7\u30eb\u30ad\u30f3\u30a8\u7d30\u80de\u306e\u5909\u6027\u3001\u30b7\u30ca\u30d7\u30b9\u6a5f\u80fd\u969c\u5bb3\u304c\u6709\u610f\u306b\u6291\u3048\u3089\u308c\u3001\u30de\u30a6\u30b9\u306e\u904b\u52d5\u5931\u8abf\u306e\u9032\u884c\u3082\u6291\u3048\u3089\u308c\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\uff08\u4e0b\uff09\u3002\u3053\u306e\u7d50\u679c\u304b\u3089ROR\u03b1\u3092\u5897\u5f37\u3059\u308b\u85ac\u306f\u3001SCA3\/MJD\u306b\u6709\u52b9\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30343032\" rel=\"noopener\" target=\"_blank\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30343032<\/a><\/p>\n<p>\u4ee5\u4e0b\u306e\u30ea\u30f3\u30af\u304b\u3089\u8ad6\u6587\u304c<strong>50\u65e5\u9593\u7121\u6599\u3067\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9<\/strong>\u3067\u304d\u307e\u3059\uff082018\u5e7412\u670813\u65e5\u307e\u3067\uff09<br \/>\nYour personalized Share Link:<br \/>\n<a href=\"https:\/\/authors.elsevier.com\/a\/1Xx-g3SZJI4B7h\" rel=\"noopener\" target=\"_blank\">https:\/\/authors.elsevier.com\/a\/1Xx-g3SZJI4B7h<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Neurobiol Dis. 2018 Oct 18. pii: S0969-9961(18)30730-7. doi: 10.1016\/j.nbd.2018.10.014. [Epub ahead of print]  [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[22],"tags":[],"class_list":["post-1018","post","type-post","status-publish","format-standard","hentry","category-publications"],"acf":[],"_links":{"self":[{"href":"https:\/\/synapse.dept.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/1018","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/synapse.dept.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/synapse.dept.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/synapse.dept.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/synapse.dept.med.gunma-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1018"}],"version-history":[{"count":13,"href":"https:\/\/synapse.dept.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/1018\/revisions"}],"predecessor-version":[{"id":1036,"href":"https:\/\/synapse.dept.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/1018\/revisions\/1036"}],"wp:attachment":[{"href":"https:\/\/synapse.dept.med.gunma-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1018"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/synapse.dept.med.gunma-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1018"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/synapse.dept.med.gunma-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1018"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}