{"id":2577,"date":"2023-03-22T12:56:22","date_gmt":"2023-03-22T03:56:22","guid":{"rendered":"https:\/\/synapse.dept.med.gunma-u.ac.jp\/?p=2577"},"modified":"2023-03-22T14:02:56","modified_gmt":"2023-03-22T05:02:56","slug":"md-phd%e3%82%b3%e3%83%bc%e3%82%b9%e3%81%ae%e5%b7%9d%e7%95%91%e5%90%9b%e5%8c%bb%e5%ad%a6%e7%a7%915%e5%b9%b4%e7%94%9f%e3%81%ae%e8%ab%96%e6%96%87%e3%81%8cmolecular-therapy-methods-clin-dev-if-5-849","status":"publish","type":"post","link":"https:\/\/synapse.dept.med.gunma-u.ac.jp\/?p=2577","title":{"rendered":"MD-PhD\u30b3\u30fc\u30b9\u306e\u5ddd\u7551\u541b(\u533b\u5b66\u79d15\u5e74\u751f)\u306e\u8ad6\u6587\u304cMolecular Therapy Methods Clin Dev (IF: 5.849)\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002"},"content":{"rendered":"<p>A blood-brain barrier-penetrating AAV2 mutant created by a brain microvasculature endothelial cell-targeted AAV2 variant<br \/>\nHayato Kawabata, Ayumu Konno, Yasunori Matsuzaki, Hirokazu Hirai<br \/>\n<strong><em>Molecular Therapy \u2013 Methods &#038; Clinical Development<\/em><\/strong><br \/>\nVolume 29, 8 June 2023, Pages 81-92<br \/>\n<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2329050123000268\" rel=\"noopener\" target=\"_blank\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2329050123000268<\/a><\/p>\n<p><strong>\u3053\u308c\u307e\u3067\u306e\u5f53\u7814\u7a76\u5ba4\u306e\u5b66\u90e8\u5b66\u751f\u300c\u7b46\u982d\u8457\u8005\u300d\u8ad6\u6587<\/strong><br \/>\n\u6fa4\u7530\u541b\u3001\u9ad8\u5c71\u541b(Cerebellum, 2010. IF: 3.648)<br \/>\n\u6589\u7530\u82f1\u6075\u3055\u3093(Gene Therapy, 2014. IF: 4.184)<br \/>\n\u661f\u91ce\u5343\u79cb\u3055\u3093(Molecular Brain, 2021. IF: 4.399)<br \/>\n\u5ddd\u7551\u52c7\u4eba\u541b(\u4eca\u56de\u3001Molecular Therapy Methods Clin Dev, 2023. IF: 5.849)<\/p>\n<p><strong>\u3053\u308c\u307e\u3067\u306e\u5f53\u7814\u7a76\u5ba4\u306e\u5b66\u90e8\u5b66\u751f\u306e\u300c\u5171\u8457\u300d\u8ad6\u6587<\/strong><br \/>\n\u6cb3\u5185\u7f8e\u9999\u3055\u3093\u3000PNAS 2022, \u5e73\u8cc0\u541b Commun Biol 2022, \u7530\u4e2d\u541b\u3001\u7bb1\u7530\u3055\u3093\u3001\u5897\u7530\u541b\u3001\u5bae\u7530\u541b\u3000Molecular Therapy 2019\u306a\u3069<\/p>\n<p>\u4eca\u56de\u3001MD-PhD\u5b66\u751f\u306e\u5ddd\u7551\u541b\u304c\u4e00\u751f\u61f8\u547d\u3001\u5b9f\u9a13\u3092\u91cd\u306d\u3001\u8ad6\u6587\u306b\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3057\u305f\u3002<\/p>\n<p>\u9759\u8108\u5185\u6295\u4e0e\u3055\u308c\u305f\u30a2\u30c7\u30ce\u968f\u4f34\u30a6\u30a4\u30eb\u30b9(AAV)\u30d9\u30af\u30bf\u30fc\u306f\u8840\u6db2\u8133\u95a2\u9580(BBB)\u3092\u900f\u904e\u3057\u307e\u305b\u3093\u304c\u3001AAV9\u306f\u4f8b\u5916\u7684\u306b\u5c11\u3057\u900f\u904e\u3057\u307e\u3059\u3002\u305d\u306e\u3088\u3046\u306a\u3053\u3068\u3067\u3001\u3053\u308c\u307e\u3067\u5831\u544a\u3055\u308c\u3066\u3044\u308bBBB\u900f\u904e\u578bAAV\u5909\u7570\u4f53\u306f\u3001\u5168\u3066AAV9\u7531\u6765\u3067\u3059\u3002<br \/>\n\u4e00\u65b9\u3001AAV2\u306f\u308f\u305a\u304b\u306a\u304c\u3089\u8133\u5fae\u7d30\u8840\u7ba1\u306e\u5185\u76ae\u7d30\u80de\u306b\u611f\u67d3\u3057\u3066\u907a\u4f1d\u5b50\u767a\u73fe\u3057\u307e\u3059\u3002AAV2\u306e\u5909\u7570\u4f53BR1\u306f\u3001\u8133\u306e\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306b\u9ad8\u52b9\u7387\u3067\u611f\u67d3\u3057\u3066\u8840\u7ba1\u5185\u76ae\u306b\u907a\u4f1d\u5b50\u767a\u73fe\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<br \/>\n\u672c\u8ad6\u6587\u3067\u306f\u3001AAV2-BR1\u306b\u4e00\u3064\u3060\u3051\u30a2\u30df\u30ce\u9178\u5909\u7570\u3092\u5165\u308c\u305fBR1N\u304cBBB\u3092\u900f\u904e\u3057\u3001\u30cb\u30e5\u30fc\u30ed\u30f3\u306b\u52b9\u7387\u7684\u306b\u907a\u4f1d\u5b50\u767a\u73fe\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u307e\u3057\u305f\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A blood-brain barrier-penetrating AAV2 mutant created by a brain microvasculature endothelial cell-targeted AA [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[22],"tags":[],"class_list":["post-2577","post","type-post","status-publish","format-standard","hentry","category-publications"],"acf":[],"_links":{"self":[{"href":"https:\/\/synapse.dept.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/2577","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/synapse.dept.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/synapse.dept.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/synapse.dept.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/synapse.dept.med.gunma-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2577"}],"version-history":[{"count":6,"href":"https:\/\/synapse.dept.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/2577\/revisions"}],"predecessor-version":[{"id":2583,"href":"https:\/\/synapse.dept.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/2577\/revisions\/2583"}],"wp:attachment":[{"href":"https:\/\/synapse.dept.med.gunma-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2577"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/synapse.dept.med.gunma-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2577"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/synapse.dept.med.gunma-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2577"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}