{"id":12,"date":"2019-09-26T11:04:14","date_gmt":"2019-09-26T02:04:14","guid":{"rendered":"https:\/\/synapse.dept.med.gunma-u.ac.jp\/vvcenter\/?page_id=12"},"modified":"2024-08-29T16:47:36","modified_gmt":"2024-08-29T07:47:36","slug":"publications","status":"publish","type":"page","link":"https:\/\/synapse.dept.med.gunma-u.ac.jp\/vvcenter\/?page_id=12","title":{"rendered":"Publications"},"content":{"rendered":"<div id=\"publications01\" class=\"content\">\n<div class=\"title cf\">\n<h3>\u30a6\u30a4\u30eb\u30b9\u30d9\u30af\u30bf\u30fc\u958b\u767a\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u767a\u8db3\u5f8c\u306e\u6210\u679c<\/h3>\n<\/div>\n<div class=\"inner\">\n<h4>2024\u5e74<\/h4>\n<ul class=\"contentsList\">\n<strong>Konno A<\/strong>, <strong>Shinohara Y<\/strong>, <strong>Hirai H<\/strong>.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39000316\/\" target=\"_blank\" rel=\"noopener noreferrer\">Production of Spinocerebellar Ataxia Type 3 Model Mice by Intravenous Injection of AAV-PHP.B Vectors.<\/a><br \/>\n<span class=\"red\">Int J Mol Sci. <\/span>2024, 25(13), 7205; https:\/\/doi.org\/10.3390\/ijms25137205<\/p>\n<p>Kinoshita K, Motomura K, Ushida K, Hirata Y, <strong>Konno A<\/strong>, <strong>Hirai H<\/strong>, Kotani S, Hitora-Imamura N, Kurauchi Y, Seki T, Katsuki H.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38704311\/\" target=\"_blank\" rel=\"noopener noreferrer\">Nurr1 overexpression in the primary motor cortex alleviates motor dysfunction induced by intracerebral hemorrhage in the striatum in mice<\/a><br \/>\n<span class=\"red\">Neurotherapeutics. <\/span>2024 May 3:e00370. doi: 10.1016\/j.neurot.2024.e00370. Online ahead of print.<\/p>\n<p><strong>Watanave M<\/strong>, <strong>Kawachi M<\/strong>, <strong>Konno A<\/strong>, <strong>Aoki R<\/strong>, <strong>Fukai Y<\/strong>, <strong>Matsuzaki Y<\/strong>, Kaneko R, <strong>Hirai H<\/strong>.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38433862\/\" target=\"_blank\" rel=\"noopener noreferrer\">Protein kinase C\u03b3 negatively regulates the intrinsic excitability in zebrin-negative cerebellar Purkinje cells<\/a><br \/>\n<span class=\"red\">Front Cell Neurosci. <\/span>2024 Feb 16;18:1349878. doi: 10.3389\/fncel.2024.1349878. eCollection 2024.<\/p>\n<p>Tan W, Ikoma Y, Takahashi Y, <strong>Konno A<\/strong>, <strong>Hirai <\/strong>H, Hirase H, Matsui K.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38311032\/\" target=\"_blank\" rel=\"noopener noreferrer\">Anxiety control by astrocytes in the lateral habenula.<\/a><br \/>\n<span class=\"red\">Neurosci Res. <\/span>2024 Feb 2:S0168-0102(24)00010-5. doi: 10.1016\/j.neures.2024.01.006. Online ahead of print.<\/p>\n<p><strong>Kawabata H<\/strong>, <strong>Konno A<\/strong>, <strong>Matsuzaki Y<\/strong>, <strong>Sato Y,<\/strong> <strong>Kawachi M<\/strong>, <strong>Aoki R<\/strong>, <strong>Tsutsumi S<\/strong>, <strong>Togai S<\/strong>, Kobayashi R, Horii T, Hatada I, <strong>Hirai H<\/strong>.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38282896\/\" target=\"_blank\" rel=\"noopener noreferrer\">Improving cell-specific recombination using AAV vectors in the murine CNS by capsid and expression cassette optimization.<\/a><br \/>\n<span class=\"red\">Mol Ther Methods Clin Dev. <\/span>2024 Jan 10. in press doi: 10.1016\/j.omtm.2024.101185\n<\/ul>\n<h4>2023\u5e74<\/h4>\n<ul class=\"contentsList\">\nMorishima M, Matsumura S, Tohyama S, Nagashima T, <strong>Konno A<\/strong>, <strong>Hirai H<\/strong>, Watabe AM.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38162000\/\" target=\"_blank\" rel=\"noopener noreferrer\">Excitatory subtypes of the lateral amygdala neurons are differentially involved in regulation of synaptic plasticity and excitation\/inhibition balance in aversive learning in mice.<\/a><br \/>\n<span class=\"red\">Front Cell Neurosci. <\/span>2023 Dec 14;17:1292822. doi: 10.3389\/fncel.2023.1292822. eCollection 2023.<\/p>\n<p>Nagashima T, Mikami K, Tohyama S, <strong>Konno A<\/strong>, <strong>Hirai H<\/strong>, Watabe AM.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38094239\/\" target=\"_blank\" rel=\"noopener noreferrer\">State-dependent modulation of positive and negative affective valences by a parabrachial nucleus-to-ventral tegmental area pathway in mice.<\/a><br \/>\n<span class=\"red\">Front Neural Circuits. <\/span> 2023 Nov 29;17:1273322. doi: 10.3389\/fncir.2023.1273322. eCollection 2023.<\/p>\n<p>Ozawa K, Nagao M, <strong>Konno A<\/strong>, Iwai Y, Vittani M, Kusk P, Mishima T, <strong>Hirai H<\/strong>, Nedergaard M, Hirase H.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37686396\/\" target=\"_blank\" rel=\"noopener noreferrer\">Astrocytic GPCR-Induced Ca2+ Signaling Is Not Causally Related to Local Cerebral Blood Flow Changes.<\/a><br \/>\n<span class=\"red\">Int J Mol Sci. <\/span> 2023 Sep 2;24(17):13590. doi: 10.3390\/ijms241713590.<\/p>\n<p>Murase S, Sakitani N, Maekawa T, Yoshino D, Takano K, <strong>Konno A<\/strong>, <strong>Hirai H<\/strong>, Saito T, Tanaka S, Shinohara K, Kishi T, Yoshikawa Y, Sakai T, Ayaori M, Inanami H, Tomiyasu K, Takashima A, Ogata T, Tsuchimochi H, Sato S, Saito S, Yoshino K, Matsuura Y, Funamoto K, Ochi H, Shinohara M, Nagao M, Sawada Y.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37414976\/\" target=\"_blank\" rel=\"noopener noreferrer\">Interstitial-fluid shear stresses induced by vertically oscillating head motion lower blood pressure in hypertensive rats and humans.<\/a><br \/>\n<span class=\"red\">Nat Biomed Eng. <\/span> 2023 Nov;7(11):1350-1373. doi: 10.1038\/s41551-023-01061-x. Epub 2023 Jul 6.<\/p>\n<p>Ichinose S, Susuki Y, <strong>Hosoi N<\/strong>, Kaneko R, Ebihara M, <strong>Hirai H<\/strong>, Iwasaki H.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37272607\/\" target=\"_blank\" rel=\"noopener noreferrer\">Interaction between Teneurin-2 and microtubules via EB proteins provides a platform for GABAA receptor exocytosis.<\/a><br \/>\n<span class=\"red\">Elife. <\/span> 2023 Jun 5;12:e83276. doi: 10.7554\/eLife.83276.<\/p>\n<p>Yaguchi K, Hagihara M, <strong>Konno A<\/strong>, <strong>Hirai H<\/strong>, Yukinaga H, Miyamichi K.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37163565\/\" target=\"_blank\" rel=\"noopener noreferrer\">Dynamic modulation of pulsatile activities of oxytocin neurons in lactating wild-type mice.<\/a><br \/>\n<span class=\"red\">PLoS One. <\/span> 2023 May 10;18(5):e0285589. doi: 10.1371\/journal.pone.0285589. eCollection 2023.<\/p>\n<p><strong>Kawabata H, Konno A, Matsuzaki Y, Hirai H.<\/strong><br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36970652\/\" target=\"_blank\" rel=\"noopener noreferrer\">A blood-brain barrier-penetrating AAV2 mutant created by a brain microvasculature endothelial cell-targeted AAV2 variant.<\/a><br \/>\n<span class=\"red\">Mol Ther Methods Clin Dev. <\/span> 2023 Mar 2;29:81-92. doi: 10.1016\/j.omtm.2023.02.016. eCollection 2023 Jun 8.<\/p>\n<p>Uggerud IM, Kr\u00e5kenes T, <strong>Hirai H<\/strong>, Vedeler CA, Schubert M.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36626013\/\" target=\"_blank\" rel=\"noopener noreferrer\">Development and Optimization of a Multilayer Rat Purkinje Neuron Culture.<\/a><br \/>\n<span class=\"red\">Cerebellum. <\/span> 2023 Jan 10. doi: 10.1007\/s12311-022-01510-4. Online ahead of print.\n<\/ul>\n<h4>2022\u5e74<\/h4>\n<ul class=\"contentsList\">\nJin M, Matsumoto S, Ayaki T, Yamakado H, Taguchi T, Togawa N, <strong>Konno A<\/strong>, <strong>Hirai H<\/strong>, Nakajima H, Komai S, Ishida R, Chiba S, Takahashi R, Takao T, Hirotsune S.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36371400\/\" target=\"_blank\" rel=\"noopener noreferrer\">DOPAnization of tyrosine in \u03b1-synuclein by tyrosine hydroxylase leads to the formation of oligomers.<\/a><br \/>\n<span class=\"red\">Nat Commun. <\/span>2022 Nov 12;13(1):6880. doi: 10.1038\/s41467-022-34555-4.<\/p>\n<p><strong>Okada Y<\/strong>, <strong>Hosoi N<\/strong>, <strong>Matsuzaki Y<\/strong>, <strong>Fukai Y<\/strong>, <strong>Hiraga A<\/strong>, Nakai J, <strong>Nitta K<\/strong>, <strong>Shinohara Y<\/strong>,<strong> Konno A<\/strong>, <strong>Hirai H<\/strong>.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36369525\/\" target=\"_blank\" rel=\"noopener noreferrer\">Development of microglia-targeting adeno-associated viral vectors as tools to study microglial behavior in vivo.<\/a><br \/>\n<span class=\"red\">Commun Biol. <\/span>2022 Nov 11;5(1):1224. doi: 10.1038\/s42003-022-04200-3.<\/p>\n<p>Ninomiya A, Amano I, Kokubo M, Takatsuru Y, Ishii S, <strong>Hirai H<\/strong>, <strong>Hosoi N<\/strong>, Koibuchi N.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36322758\/\" target=\"_blank\" rel=\"noopener noreferrer\">Long-term depression-inductive stimulation causes long-term potentiation in mouse Purkinje cells with a mutant thyroid hormone receptor.<\/a><br \/>\n<span class=\"red\">Proc Natl Acad Sci USA. <\/span>2022 Nov 8;119(45):e2210645119. doi: 10.1073\/pnas.2210645119. Epub 2022 Nov 2.<\/p>\n<p>Morizawa YM, Matsumoto M, Nakashima Y, Endo N, Aida T, Ishikane H, Beppu K, Moritoh S, Inada H, Osumi N, Shigetomi E, Koizumi S, Yang G, <strong>Hirai H<\/strong>, Tanaka K, Tanaka KF, Ohno N, Fukazawa Y, Matsui K.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36319770\/\" target=\"_blank\" rel=\"noopener noreferrer\">Synaptic pruning through glial synapse engulfment upon motor learning.<\/a><br \/>\n<span class=\"red\">Nat Neurosci. <\/span>2022 Nov;25(11):1458-1469. doi: 10.1038\/s41593-022-01184-5. Epub 2022 Nov 1.<\/p>\n<p>Wang X, Delle C, Asiminas A, Akther S, Vittani M, Br\u00f8gger P, Kusk P, Vo CT, Radovanovic T, <strong>Konno A<\/strong>, <strong>Hirai H<\/strong>, Fukuda M, Weikop P, Goldman SA, Nedergaard M, Hirase H.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36313804\/\" target=\"_blank\" rel=\"noopener noreferrer\">Liver-secreted fluorescent blood plasma markers enable chronic imaging of the microcirculation.<\/a><br \/>\n<span class=\"red\">Cell Rep Methods. <\/span>2022 Sep 21;2(10):100302. doi: 10.1016\/j.crmeth.2022.100302. eCollection 2022 Oct 24.<\/p>\n<p>Shuvaev AN, Belozor OS, Mozhei OI, Shuvaev AN, Fritsler YV, Khilazheva ED, Mosyagina AI, <strong>Hirai H<\/strong>, Teschemacher AG, Kasparov S.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35883691\/\" target=\"_blank\" rel=\"noopener noreferrer\">Indirect Negative Effect of Mutant Ataxin-1 on Short- and Long-Term Synaptic Plasticity in Mouse Models of Spinocerebellar Ataxia Type 1.<\/a><br \/>\n<span class=\"red\">Cells. <\/span>2022 Jul 20;11(14):2247. doi:10.3390\/cells11142247<\/p>\n<p>Tokuyama T, Uosaki H, Sugiura A, Nishitai G, Takeda K, Nagashima S, Shiiba I, Ito N, Amo T, Mohri S, Nishimura A, Nishida M, <strong>Konno A<\/strong>, <strong>Hirai H<\/strong>, Ishido S, Yoshizawa T, Shindo T, Takada S, Kinugawa S, Inatome R, Yanagi S<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35789860\/\" target=\"_blank\" rel=\"noopener noreferrer\">Protective roles of MITOL against myocardial senescence and ischemic injury partly via Drp1 regulation.<\/a><br \/>\n<span class=\"red\">iScience. <\/span>2022 Jun 11;25(7):104582. doi: 10.1016\/j.isci.2022.104582.<\/p>\n<p>Inada K, Hagihara M, Tsujimoto K, Abe T, <strong>Konno A<\/strong>, <strong>Hirai H<\/strong>, Kiyonari H, Miyamichi K.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35443152\/\" target=\"_blank\" rel=\"noopener noreferrer\">Plasticity of neural connections underlying oxytocin-mediated parental behaviors of male mice.<\/a><br \/>\n<span class=\"red\">Neuron. <\/span>2022 Jun 15;110(12):2009-2023.e5. doi: 10.1016\/j.neuron.2022.03.033. Epub 2022 Apr 19.<\/p>\n<p>Ueda E, Ohta T, <strong>Konno A<\/strong>, <strong>Hirai H<\/strong>, Kurauchi Y, Katsuki H, Seki T.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35406792\/\" target=\"_blank\" rel=\"noopener noreferrer\">D-Cysteine Activates Chaperone-Mediated Autophagy in Cerebellar Purkinje Cells via the Generation of Hydrogen Sulfide and Nrf2 Activation.<\/a><br \/>\n<span class=\"red\">Cells. <\/span>2022 Apr 5;11(7):1230. doi: 10.3390\/cells11071230.<\/p>\n<p><strong>Hirai H, Fukai Y, Konno A, Hosoi N.<\/strong><br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35218526\/\" target=\"_blank\" rel=\"noopener noreferrer\">Electrophysiological and Imaging Analysis of GFP-Tagged Protein Kinase C \u03b3 Translocation in Cerebellar Purkinje Cells.<\/a><br \/>\n<span class=\"red\">Cerebellum. <\/span>2022 Oct;21(5):776-783. doi: 10.1007\/s12311-022-01384-6. Epub 2022 Feb 26.<\/p>\n<p>Sakai A, Yasui T, <strong>Watanave M<\/strong>, Tatsumi R, Yamamoto Y, Takano W, Tani Y, Okamura I, <strong>Hirai H<\/strong>, Takeda S.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35194900\/\" target=\"_blank\" rel=\"noopener noreferrer\">Development of novel potent ligands for GPR85, an orphan G protein-coupled receptor expressed in the brain.<\/a><br \/>\n<span class=\"red\">Genes Cells. <\/span>2022 May;27(5):345-355. doi: 10.1111\/gtc.12931. Epub 2022 Mar 1.<\/p>\n<p><strong>Watanave M<\/strong>, <strong>Takahashi N<\/strong>, <strong>Hosoi N<\/strong>, <strong>Konno A<\/strong>, <strong>Yamamoto H<\/strong>, <strong>Yasui H,<\/strong> <strong>Kawachi M<\/strong>, Horii T, <strong>Matsuzaki Y<\/strong>, Hatada I, <strong>Hirai H<\/strong>.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35145028\/\" target=\"_blank\" rel=\"noopener noreferrer\">Protein kinase C\u03b3 in cerebellar Purkinje cells regulates Ca 2+-activated large-conductance K + channels and motor coordination<\/a><br \/>\n<span class=\"red\">Proc Natl Acad Sci U S A. <\/span>2022 Feb 15;119(7):e2113336119. doi: 10.1073\/pnas.2113336119.<\/p>\n<p>Suzuki A, Kosugi S, Murayama E, Sasakawa E, Ohkawa N, <strong>Konno A<\/strong>, <strong>Hirai H<\/strong>, Inokuchi K.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35017495\/\" target=\"_blank\" rel=\"noopener noreferrer\">A cortical cell ensemble in the posterior parietal cortex controls past experience-dependent memory updating.<\/a><br \/>\n<span class=\"red\">Nat Commun. <\/span>2022 Jan 11;13(1):41. doi: 10.1038\/s41467-021-27763-x<\/p>\n<p>Ninomiya A, Mshaty A, Haijima A, Yajima H, Kokubo M, Khairinisa MA, Ariyani W, Fujiwara Y, Ishii S, <strong>Hosoi N<\/strong>, <strong>Hirai H<\/strong>, Amano I, Koibuchi N.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34871666\/\" target=\"_blank\" rel=\"noopener noreferrer\">The neurotoxic effect of lactational PFOS exposure on cerebellar functional development in male mice.<\/a><br \/>\n<span class=\"red\">Food Chem Toxicol. <\/span>2022 Jan;159:112751. doi: 10.1016\/j.fct.2021.112751. Epub 2021 Dec 3.\n<\/ul>\n<h4>2021\u5e74<\/h4>\n<ul class=\"contentsList\">\n<li>Cendelin J, Cvetanovic M, Gandelman M, <strong>Hirai H<\/strong>, Orr HT, Pulst SM, Strupp M, Tichanek F, Tuma J, Manto M.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34378174\/\" target=\"_blank\" rel=\"noopener noreferrer\">Consensus Paper: Strengths and Weaknesses of Animal Models of Spinocerebellar Ataxias and Their Clinical Implications.<\/a><br \/>\n<span class=\"red\">Cerebellum. <\/span> 2021 Aug 10. doi: 10.1007\/s12311-021-01311-1. Online ahead of print.<\/li>\n<li>Kawakami R, Matsui M, <strong>Konno A<\/strong>, Kaneko R, Shrestha S, Shrestha S, Sunaga H, Hanaoka H, Goto S, Hosojima M, Kabasawa H, Obokata M, Koitabashi N, Matsui H, Sasaki T, Saito A, Yanagita M, <strong>Hirai H<\/strong>, Kurabayashi M, Iso T.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34370295\/\" target=\"_blank\" rel=\"noopener noreferrer\">Urinary FABP1 is a biomarker for impaired proximal tubular protein reabsorption and is synergistically enhanced by concurrent liver injury.<\/a><br \/>\n<span class=\"red\">J Pathol. <\/span> 2021 Dec;255(4):362-373. doi: 10.1002\/path.5775. Epub 2021 Sep 1.<\/li>\n<li>Ohta T, Morikawa Y, Sato M, <strong>Konno A<\/strong>, <strong>Hirai H<\/strong>, Kurauchi Y, Hisatsune A, Katsuki H, Seki T.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34157318\/\" target=\"_blank\" rel=\"noopener noreferrer\">Therapeutic potential of d-cysteine against in vitro and in vivo models of spinocerebellar ataxia.<\/a><br \/>\n<span class=\"red\">Exp Neurol. <\/span> 2021 Sep;343:113791. doi: 10.1016\/j.expneurol.2021.113791. Epub 2021 Jun 19.<\/li>\n<li><strong>Radhiyanti PT<\/strong>, <strong>Konno A<\/strong>, <strong>Matsuzaki Y<\/strong>, <strong>Hirai H<\/strong>.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33989730\/\" target=\"_blank\" rel=\"noopener noreferrer\">Comparative study of neuron-specific promoters in mouse brain transduced by intravenously administered AAV-PHP.eB.<\/a><br \/>\n<span class=\"red\">Neurosci Lett. <\/span> 2021 Jun 21;756:135956. doi: 10.1016\/j.neulet.2021.135956. Epub 2021 May 11.<\/li>\n<li>Nagao S, <strong>Hirai H<\/strong>, Kano M, Yuzaki M.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33892899\/\" target=\"_blank\" rel=\"noopener noreferrer\">Masao Ito-A Visionary Neuroscientist with a Passion for the Cerebellum.<\/a><br \/>\n<span class=\"red\">Neuroscience.<\/span> 2021 May 10;462:1-3. doi: 10.1016\/j.neuroscience.2021.02.028.<\/li>\n<li>Shuvaev AN, Belozor OS, Mozhei O, Yakovleva DA, Potapenko IV, Shuvaev AN, Smolnikova MV, Salmin VV, Salmina AB, <strong>Hirai H<\/strong>, Teschemacher AG, Kasparov S.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33753288\/\" target=\"_blank\" rel=\"noopener noreferrer\">Chronic optogenetic stimulation of Bergman glia leads to dysfunction of EAAT1 and Purkinje cell death, mimicking the events caused by expression of pathogenic ataxin-1.<\/a><br \/>\n<span class=\"red\">Neurobiol Dis.<\/span> 2021 Jul;154:105340. doi: 10.1016\/j.nbd.2021.105340. Epub 2021 Mar 19.<\/li>\n<li>Sugimoto H, Horii T, Hirota JN, Sano Y, Shinoda Y, <strong>Konno A<\/strong>, <strong>Hirai H<\/strong>, Ishizaki Y, Hirase H, Hatada I, Furuichi T, Sadakata T.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33712038\/\" target=\"_blank\" rel=\"noopener noreferrer\">The Ser19Stop single nucleotide polymorphism (SNP) of human PHYHIPL affects the cerebellum in mice.<\/a><br \/>\n<span class=\"red\">Mol Brain.<\/span> 2021 Mar 12;14(1):52. doi: 10.1186\/s13041-021-00766-x.<\/li>\n<li><strong>Hoshino C<\/strong>, <strong>Konno A<\/strong>, <strong>Hosoi N<\/strong>, Kaneko R, Mukai R, Nakai J, <strong>Hirai H<\/strong>.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33588899\/\" target=\"_blank\" rel=\"noopener noreferrer\">GABAergic neuron-specific whole-brain transduction by AAV-PHP.B incorporated with a new GAD65 promoter.<\/a><br \/>\n<span class=\"red\">Mol Brain.<\/span> 2021 Feb 15;14(1):33. doi: 10.1186\/s13041-021-00746-1.<\/li>\n<li>Ohgami N, <strong>Iizuka A<\/strong>, <strong>Hirai H<\/strong>, Yajima I, Iida M, Shimada A, Tsuzuki T, Jijiwa M, Asai N, Takahashi M, Kato M.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33561442\/\" target=\"_blank\" rel=\"noopener noreferrer\">Loss-of-function mutation of c-Ret causes cerebellar hypoplasia in mice with Hirschsprung disease and Down&#8217;s syndrome.<\/a><br \/>\n<span class=\"red\">J Biol Chem.<\/span> Jan-Jun 2021;296:100389. doi: 10.1016\/j.jbc.2021.100389. Epub 2021 Feb 6.<\/li>\n<\/ul>\n<h4>2020\u5e74<\/h4>\n<ul class=\"contentsList\">\n<li>Inoue A, Kobayashi T, <strong>Hirai H<\/strong>, Kanaya N, Kohara K.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33377060\/\" target=\"_blank\" rel=\"noopener noreferrer\">Protocol for BATTLE-1EX: A High-Resolution Imaging Method to Visualize Whole Synaptic Structures and their Components in the Nervous System.<\/a><br \/>\n<span class=\"red\">J STAR Protoc. <\/span> 2020 Nov 25;1(3):100166. doi: 10.1016\/j.xpro.2020.100166. eCollection 2020 Dec 18.<\/li>\n<li><strong>Konno A, Hirai H.<\/strong><br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32810474\/\" target=\"_blank\" rel=\"noopener noreferrer\">Efficient whole brain transduction by systemic infusion of minimally purified AAV-PHP.eB.<\/a><br \/>\n<span class=\"red\" j=\"\" neurosci=\"\" methods=\"\" span=\"\">J Neurosci Methods.<span style=\"color: #000000;\"> 2020 Aug 15;346:108914. doi: 10.1016\/j.jneumeth.2020.108914.<\/span><\/span><\/li>\n<li><span>Sato M, Ohta T, Morikawa Y, Konno A, Hirai H, Kurauchi Y, Hisatsune A, Katsuki H, Seki T.<\/span><br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32722888\/\" target=\"_blank\" rel=\"noopener noreferrer\">Ataxic phenotype and neurodegeneration are triggered by the impairment of chaperone-mediated autophagy in cerebellar neurons.<\/a><br \/>\n<span class=\"red\" neuropathol=\"\" appl=\"\" neurobiol=\"\" span=\"\">Neuropathol Appl Neurobiol. <span style=\"color: #000000;\">2020 Jul 28. doi: 10.1111\/nan.12649.<\/span><\/span><\/li>\n<li><span>Sato M, Ueda E, Konno A, Hirai H, Kurauchi Y, Hisatsune A, Katsuki H, Seki T.<\/span><br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32487317\/\" target=\"_blank\" rel=\"noopener noreferrer\">Glucocorticoids negatively regulates chaperone mediated autophagy and microautophagy.<\/a><br \/>\n<span class=\"red\" biochem=\"\" biophys=\"\" res=\"\" commun=\"\" span=\"\">Biochem Biophys Res Commun. <span style=\"color: #000000;\">2020 Jul 12;528(1):199-205. doi: 10.1016\/j.bbrc.2020.04.132.<\/span><\/span><\/li>\n<li><span>Kohara K, Inoue A, Nakano Y, Hirai H, Kobayashi T, Maruyama M, Baba R, Kawashima C.<\/span><br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32629613\/\" target=\"_blank\" rel=\"noopener noreferrer\">BATTLE: Genetically Engineered Strategies for Split-Tunable Allocation of Multiple Transgenes in the Nervous System.<\/a><br \/>\n<span class=\"red\" iscience=\"\" span=\"\">iScience. <span style=\"color: #000000;\">2020 Jun 26;23(6):101248. doi: 10.1016\/j.isci.2020.101248<\/span><\/span><\/li>\n<li><span>Chao OY, Marron Fernandez de Velasco E, Pathak SS, Maitra S, Zhang H, Duvick L, Wickman K, Orr HT, Hirai H, Yang YM.<\/span><br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32179875\" target=\"_blank\" rel=\"noopener noreferrer\">Targeting Inhibitory Cerebellar Circuitry to Alleviate Behavioral Deficits in a Mouse Model for Studying Idiopathic Autism.<\/a><br \/>\n<span class=\"red\">Neuropsychopharmacology.<span>\u00a0<\/span><\/span><span>2020 Mar 16. doi: 10.1038\/s41386-020-0656-5.<\/span><\/li>\n<li><span>Yasui H, Matsuzaki Y, Konno A, Hirai H.<\/span><br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32278059\/\" target=\"_blank\" rel=\"noopener noreferrer\">Global knockdown of retinoid-related orphan receptor \u03b1 in mature Purkinje cells reveals aberrant cerebellar phenotypes of spinocerebellar ataxia.<\/a><br \/>\n<span class=\"red\">Neuroscience.<span>\u00a0<\/span><\/span><span>2020 Apr. doi: 10.1016\/j.neuroscience.2020.04.004.<\/span><\/li>\n<li>Oe Y, Wang X, Patriarchi T, Konno A, Ozawa K, Yahagi K, Hirai H, Tsuboi T, Kitaguchi T, Tian L, McHugh TJ, Hirase H.<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31980655\" target=\"_blank\" rel=\"noopener noreferrer\">Distinct temporal integration of noradrenaline signaling by astrocytic second messengers during vigilance.<\/a><br \/>\n<span class=\"red\">Nature Communications.<span>\u00a0<\/span><\/span>2020 Jan 24;11(1):471. doi: 10.1038\/s41467-020-14378-x.<\/li>\n<\/ul>\n<h4>2019\u5e74<\/h4>\n<ul class=\"contentsList\">\n<li><span>Matsumoto K, Mitani TT, Horiguchi SA, Kaneshiro J, Murakami TC, Mano T, Fujishima H, Konno A, Watanabe TM, Hirai H, Ueda HR.<\/span><br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31748753\" target=\"_blank\" rel=\"noopener noreferrer\">Advanced CUBIC tissue clearing for whole-organ cell profiling.<\/a><br \/>\n<span class=\"red\">Nature Protocols,<\/span><span>\u00a02019 Dec;14(12):3506-3537.<\/span><\/li>\n<\/ul>\n<h3>\u30a6\u30a4\u30eb\u30b9\u30d9\u30af\u30bf\u30fc\u958b\u767a\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u767a\u8db3\u524d\u306e\u6210\u679c<\/h3>\n<\/div>\n<div class=\"inner\">\n<ul class=\"contentsList\">\n<li>\n<h4>\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u7279\u7570\u7684AAV\u30d9\u30af\u30bf\u30fc<\/h4>\n<p>Shinohara Y, Konno A, Takahashi N, Matsuzaki Y, Kishi S, Hirai H.<br \/>\nViral Vector-Based Dissection of Marmoset GFAP Promoter in Mouse and Marmoset Brains.<br \/>\n<em><strong>PLoS One<\/strong><\/em>. 2016 Aug 29;11(8):e0162023.<\/li>\n<li>\n<h4>\u30cb\u30e5\u30fc\u30ed\u30f3\u7279\u7570\u7684AAV\u30d9\u30af\u30bf\u30fc<\/h4>\n<p>Shinohara Y, Ohtani T, Konno A, Hirai H<br \/>\nViral Vector-Based Evaluation of Regulatory Regions in the Neuron-Specific Enolase (NSE) Promoter in Mouse Cerebellum In Vivo.<br \/>\n<em><strong>Cerebellum<\/strong><\/em>. 2017 Dec;16(5-6):913-922.<\/li>\n<li>\n<h4>\u30d7\u30eb\u30ad\u30f3\u30a8\u7d30\u80de\u7279\u7570\u7684AAV\u30d9\u30af\u30bf\u30fc<\/h4>\n<p>Nitta K, Matsuzaki Y, Konno A, Hirai H<br \/>\nMinimal Purkinje Cell-Specific PCP2\/L7 Promoter Virally Available for Rodents and Non-human Primates.<br \/>\n<em><strong>Mol Ther Methods Clin Dev<\/strong><\/em>. 2017 Jul 27;6:159-170.<\/p>\n<p><a><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/synapse.dept.med.gunma-u.ac.jp\/vvcenter\/wp-content\/uploads\/2019\/09\/publications01.png\" alt=\"\" width=\"154\" height=\"200\" class=\"alignleft size-full wp-image-47\" \/>\u3000<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/synapse.dept.med.gunma-u.ac.jp\/vvcenter\/wp-content\/uploads\/2019\/09\/publications02.png\" alt=\"\" width=\"150\" height=\"46\" class=\"alignleft size-medium wp-image-48\" \/><\/a><a style=\"letter-spacing: 0.02em; background-color: #f2f2f2;\">\u304b\u3089\u5165\u624b\u53ef\u80fd: <\/a><a href=\"https:\/\/www.addgene.org\/126462\/\">pAAV\/L7-6-GFP-WPRE (Plasmid #126462)<\/a><\/li>\n<li>\n<h4>AAV\u30ab\u30d7\u30b7\u30c9\u306b\u5bfe\u3059\u308b\u4e2d\u548c\u6297\u4f53\u7523\u751f<\/h4>\n<p>Shinohara Y, Konno A, Nitta K, Matsuzaki Y, Yasui H, Suwa J, Hiromura K, Hirai H.<br \/>\nEffects of Neutralizing Antibody Production on AAV-PHP.B-Mediated Transduction of the Mouse Central Nervous System.<br \/>\n<em><strong>Mol Neurobiol<\/strong><\/em>. 2019 Jun;56(6):4203-4214.<\/li>\n<li>\n<h4>\u30de\u30fc\u30e2\u30bb\u30c3\u30c8\u4e2d\u67a2\u795e\u7d4c\u7cfb\u3078\u306e\u907a\u4f1d\u5b50\u767a\u73fe<\/h4>\n<p>Matsuzaki Y, Konno A, Mochizuki R, Shinohara Y, Nitta K, Okada Y, Hirai H<br \/>\nIntravenous administration of the adeno-associated virus-PHP.B capsid fails to upregulate transduction efficiency in the marmoset brain.<br \/>\n<em><strong>Neurosci Lett<\/strong><\/em>. 2018 Feb 5;665:182-188.<\/p>\n<hr \/>\n<p>Matsuzaki Y, Konno A, Mukai R, Honda F, Hirato M, Yoshimoto Y, Hirai H.<br \/>\nTransduction Profile of the Marmoset Central Nervous System Using Adeno-Associated Virus Serotype 9 Vectors.<br \/>\n<em><strong>Mol Neurobiol<\/strong><\/em>. 2017 Apr;54(3):1745-1758.<\/li>\n<li>\n<h4>\u8840\u6db2\u8133\u95a2\u9580\u900f\u904e\u578bAAV\u30d9\u30af\u30bf\u30fc<\/h4>\n<p>Matsuzaki Y, Tanaka M, Hakoda S, Masuda T, Miyata R, Konno A, Hirai H<br \/>\nNeurotropic Properties of AAV-PHP.B Are Shared among Diverse Inbred Strains of Mice.<br \/>\n<em><strong>Mol Ther<\/strong><\/em>. 2019 Apr 10;27(4):700-704. Epub 2019 Feb 28.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div id=\"publications02\" class=\"content\">\n<div class=\"title cf\">\n<h3>\u65e5\u672c\u8a9e\u7dcf\u8aac\u7b49<\/h3>\n<\/div>\n<div class=\"inner\">\n<ul class=\"contentsList\">\n<li>\n<h4>\u5e73\u4e95\u5b8f\u548c<\/h4>\n<p>\u30a6\u30a4\u30eb\u30b9\u30d9\u30af\u30bf\u30fc\u9759\u8108\u6295\u4e0e\u306b\u3088\u308b\u810a\u9ac4\u5c0f\u8133\u5909\u6027\u75c7\u52d5\u7269\u30e2\u30c7\u30eb\u306e\u4f5c\u51fa<br \/>\nClinical Neuroscience. 2019 Vol.37 (19\u5e74) 08\u6708\u53f7: 998-1002<\/li>\n<li>\n<h4>\u4eca\u91ce\u6b69, \u5e73\u4e95\u5b8f\u548c<\/h4>\n<p>\u30a6\u30a4\u30eb\u30b9\u30d9\u30af\u30bf\u30fc\u306e\u9759\u8108\u6295\u4e0e\u306b\u3088\u308b\u30de\u30a6\u30b9\u8133\u5168\u57df\u3078\u306e\u907a\u4f1d\u5b50\u5c0e\u5165<br \/>\n\u5b9f\u9a13\u533b\u5b66. 2019; 37(4): 581-587<\/li>\n<li>\n<h4>\u5e73\u4e95\u5b8f\u548c<\/h4>\n<p>\u30c8\u30d4\u30c3\u30af\uff1a<a href=\"https:\/\/bsd.neuroinf.jp\/wiki\/%E9%81%BA%E4%BC%9D%E5%AD%90%E5%B0%8E%E5%85%A5\" target=\"_blank\" rel=\"noopener noreferrer\">\u907a\u4f1d\u5b50\u5c0e\u5165<\/a><br \/>\n\u8133\u79d1\u5b66\u8f9e\u5178. 2018. doi:10.14931\/bsd.7623<\/li>\n<li>\n<h4>\u5e73\u4e95\u5b8f\u548c<\/h4>\n<p>\u30c8\u30d4\u30c3\u30af\uff1a<a href=\"https:\/\/bsd.neuroinf.jp\/wiki\/%E3%82%A6%E3%82%A4%E3%83%AB%E3%82%B9%E3%83%99%E3%82%AF%E3%82%BF%E3%83%BC\" target=\"_blank\" rel=\"noopener noreferrer\">\u30a6\u30a4\u30eb\u30b9\u30d9\u30af\u30bf\u30fc<\/a><br \/>\n\u8133\u79d1\u5b66\u8f9e\u5178. 2018. doi:10.14931\/bsd.7632<\/li>\n<\/ul>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u30a6\u30a4\u30eb\u30b9\u30d9\u30af\u30bf\u30fc\u958b\u767a\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u767a\u8db3\u5f8c\u306e\u6210\u679c 2024\u5e74 Konno A, Shinohara Y, Hirai H. Production of Spinocerebellar Ataxia Type 3 Model  [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":11,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-12","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/synapse.dept.med.gunma-u.ac.jp\/vvcenter\/index.php?rest_route=\/wp\/v2\/pages\/12","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/synapse.dept.med.gunma-u.ac.jp\/vvcenter\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/synapse.dept.med.gunma-u.ac.jp\/vvcenter\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/synapse.dept.med.gunma-u.ac.jp\/vvcenter\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/synapse.dept.med.gunma-u.ac.jp\/vvcenter\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=12"}],"version-history":[{"count":12,"href":"https:\/\/synapse.dept.med.gunma-u.ac.jp\/vvcenter\/index.php?rest_route=\/wp\/v2\/pages\/12\/revisions"}],"predecessor-version":[{"id":340,"href":"https:\/\/synapse.dept.med.gunma-u.ac.jp\/vvcenter\/index.php?rest_route=\/wp\/v2\/pages\/12\/revisions\/340"}],"wp:attachment":[{"href":"https:\/\/synapse.dept.med.gunma-u.ac.jp\/vvcenter\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=12"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}