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2014
論文発表
Irie T, Matsuzaki Y, Sekino Y, Hirai H.
The Journal of Physiology 2014 Jan 1;592(Pt 1):229-47.
Konno A, Shuvaev AN, Miyake N, Miyake K, Iizuka A, Matsuura S, Huda F, Nakamura K, Yanagi S, Shimada T, Hirai H.
The Cerebellum 2014 Feb;13(1):29-41.
Matsuzaki Y, Oue M, Hirai H.
The Journal of Neuroscience Methods 2014 Feb 15;223:133-43.
Matsuura S, Shuvaev AN, Iizuka A, Nakamura K, Hirai H.
The Cerebellum 2014 Jun;13(3):323-30.
Okonogi N, Nakamura K, Suzuki Y. Suto N. Suzue K. Kaminama T. Nakano T. Hirai H.
Cranial irradiation induces bone marrow-derived microglia in adult mouse brain tissue.
Journal of Radiation Research 2014 Jul;55(4):713-9.
Uesaka N, Uchigashima M, Mikuni T, Nakazawa T, Nakao H, Hirai H, Aiba A, Watanabe M, Kano M.
Retrograde semaphorin signaling regulates synapse elimination in the developing mouse brain.
Science 2014 May 30;344(6187):1020-3.
Huda F, Konno A. Matsuzaki Y. Goenawan H. Miyake K. Shimada T and Hirai H.
Molecular Therapy-Methods & Clinical Development 2014 Aug 6.
Saida H, Matsuzaki Y, Takayama K, Iizuka A, Konno A, Yanagi S, Hirai H.
Gene Therapy 2014 Sep;21(9):820-7.
Takahashi H, Adachi N, Shirafuji T, Danno S, Ueyama T, Vendruscolo M, Shuvaev AN, Sugimoto T, Seki T, Hamada D, Irie K, Hirai H, Sakai N, Saito N.
Human Molecular Genetics 2014 Sep 12.
Yoshihara S, Takahashi H, Nishimura N, Kinoshita M, Asahina R, Kitsuki M. Tatsumi K, Furukawa-Hibi Y, Hirai H, Nagai T, Yamada K, Tsuboi A.
Cell Reports 2014 Aug 7;8(3):843-57.
Nakamura K, Mieda T, Suto N, Matsuura S, Hirai H.
Mesenchymal Stem Cells as a Potential Therapeutic Tool for Spinocerebellar Ataxia.
Cerebellum 2014 Oct 4. [Epub ahead of print]
Uesaka N, Uchigashima M, Mikuni T, Hirai H, Watanabe M, Kano M.
Retrograde Signaling for Climbing Fiber Synapse Elimination.
Cerebellum 2014 Oct 23. [Epub ahead of print]
2013
論文発表
Nóbrega C, Nascimento-Ferreira I, Onofre I, Albuquerque D, Hirai H,Déglon N, de Almeida LP.
PLoS One 2013;8(1):e52396.
Takechi Y, Mieda T, Iizuka A, Toya S, Suto N, Takagishi K, Nakazato Y, Nakamura K, Hirai H.
Impairment of spinal motor neurons in spinocerebellar ataxia type 1-knock-in mice.
Neuroscience Letters 2013 Feb 22;535:67-72.
Liu HX, Lopatina O, Higashida C, Fujimoto H, Akther S, Inzhutova A, Liang M, Zhong J, Tsuji T, Yoshihara T, Sumi K, Ishiyama M, Ma WJ, Ozaki M, Yagitani S, Yokoyama S, Mukaida N, Sakurai T, Hori O, Yoshioka K, Hirao A, Kato Y, Ishihara K, Kato I, Okamoto H, Cherepanov SM, Salmina AB, Hirai H, Asano M, Brown DA, Nagano I, Higashida H
Displays of paternal mouse pup retrieval following communicative interaction with maternal mates.
Nature Communications 2013;4:1346.
Yamaura H. Hirai H, Yanagihara D.
Postural dysfunction in a transgenic mouse model of spinocerebellar ataxia type 3.
Neuroscience 2013 Jul 23;243:126-35.
Mikuni T, Uesaka N, Okuno H, Hirai H, Deisseroth K, Bito H, Kano M.
Neuron 2013 Jun 19;78(6):1024-35.
Nascimento-Ferreira I, Nóbrega C, Vasconcelos-Ferreira A, Onofre I, Albuquerque D, Aveleira C, Hirai H, Déglon N, Pereira de Almeida L.
Brain 2013 Jul;136(Pt 7):2173-88.
Akther S, Korshnova N, Zhong J, Liang M, Cherepanov SM, Lopatina O, Komleva YK, Salmina AB, Nishimura T, Fakhrul AA, Hirai H, Kato I, Yamamoto Y, Takasawa S, Okamoto H, Higashida H.
CD38 in the nucleus accumbens and oxytocin are related to paternal behavior in mice.
Molecular Brain 2013 Sep 23;6(1):41.
Miki T, Hirai H, Takahashi T.
The Journal of Neuroscience 2013 Nov 27;33(48):18755-63.
総説
平井宏和
小脳と運動失調 小脳はなにをしているのか（アクチュアル 脳・神経疾患の臨床）
（ISBN: 978-4-521-73442-2) 辻省次(編集), 西澤正豊(編集) 中山書店
学会発表
Hirokazu Hirai
Progress of spinocerebellar ataxia research on pathology, model animals and gene/stem cell therapies: Toward clinical application
第19回日本遺伝子治療学会学術集会・シンポジウム(S2-2) 2013年7月5日
Hirokazu Hirai
Virus-mediated highly efficient and cell-type specific gene expression in the cerebellum – Modulation of cathepsin K activity and development of unique promoters –
第90回日本生理学会大会・シンポジウム(1S13E-1) 2013年3月27日
2012
論文発表
Jin D, Muramatsu SI, Shimizu N, Yokoyama S, Hirai H, Yamada K, Liu HX, Higashida C, Hashii M, Higashida A, Asano M, Ohkuma S, Higashida H.
Neurochemistry International 2012 Nov;61(6):907-12
Yoshihara SI, Takahashi H, Nishimura N, Naritsuka H, Shirao T, Hirai H, Yoshihara Y, Mori K, Stern PL, Tsuboi A.
Journal of Neuroscience 2012 Feb 8;32(6):2217-2226.
Hirai H.
Basic research on cerebellar gene therapy using lentiviral vectors.
The Cerebellum 2012 Jun 11(2): 443-5
Uesaka N. Mikuni T. Hashimoto K. Hirai H. Sakimura K. Kano M.
Journal of Neuroscience 2012 Aug 22; 32(34): 11657-11670
Goenawan H. Hirai H.
Journal of NeuroVirology 2012 Dec;18(6):521-31
Oue M, Handa H, Matsuzaki Y, Suzue K, Murakami H, Hirai H.
PLoS One 2012;7(11):e51015.
総説
平井宏和
News & Hot Paper Digest
「神経変性疾患でなぜ神経細胞が死ぬのか？」
羊土社・実験医学 Vol.30 No.1, 64-65, 2012 Jan
2011
論文発表
Mitsumura K, Hosoi N, Furuya N, Hirai H.
The Journal of Physiology 2011 May 9; 589:3191-3209. Epub 2011 Jul 1
Shuvaev AN, Horiuchi H, Seki T, Goenawan H, Irie T, Iizuka A, Sakai N, Hirai H.
The Journal of Neuroscience 2011 Oct 5;31(40):14324-34.
Hirai H.
Basic research on cerebellar gene therapy using lentiviral vectors.
The Cerebellum 2011 Nov 26. [Epub ahead of print]
総説
Hirai H, Iizuka A.
Chapter 22. Recent developments in gene therapy research targeted to cerebellar disorders.
Gene Therapy Applications (ISBN:978-953-307-541-9). Edited by Chunsheng Kang, Publisher: InTech, Aug 2011.
平井宏和
News & Hot Paper Digest
「多発性硬化症の最初の病変は脱髄ではなく軸索変性である」
羊土社・実験医学 Vol.29 No.13, 2130, 2011 Aug
平井宏和
News & Hot Paper Digest
「脳のマクロファージ、ミクログリアはどこからやってくるのか？」
羊土社・実験医学 Vol.29 No.6, 904-905, 2011 Apr
2010
論文発表
Sasaki J, Kofuji S, Itoh R, Momiyama T, Takayama K, Murakami H, Chida S, Tsuya Y, Takasuga S, Eguchi S, Asanuma K, Horie Y, Miura K, Davies EM, Mitchell C, Yamazaki M, Hirai H, Takenawa T, Suzuki A, Sasaki T.
The PtdIns(3,4)P(2) phosphatase INPP4A is a suppressor of excitotoxic neuronal death.
Nature 2010 May 27;465(7297):497-501. Epub 2010 May 12.
Munesue T, Yokoyama S, Nakamura K, Anitha A, Yamada K, Hayashi K, Asaka T, Liu HX, Jin D, Koizumi K, Islam MS, Huang JJ, Ma WJ, Kim UH, Kim SJ, Park K, Kim D, Kikuchi M, Ono Y, Nakatani H, Suda S, Miyachi T, Hirai H, Salmina A, Pichugina YA, Soumarokov AA, Takei N, Mori N, Tsujii M, Sugiyama T, Yagi K, Yamagishi M, Sasaki T, Yamasue H, Kato N, Hashimoto R, Taniike M, Hayashi Y, Hamada J, Suzuki S, Ooi A, Noda M, Kamiyama Y, Kido MA, Lopatina O, Hashii M, Amina S, Malavasi F, Huang EJ, Zhang J, Shimizu N, Yoshikawa T, Matsushima A, Minabe Y, Higashida H.
Two genetic variants of CD38 in subjects with autism spectrum disorder and controls.
Neuroscience Research 2010 Jun;67(2):181-91. Epub 2010 May 1
Sawada Y, Kajiwara G, Iizuka A, Takayama K, Shuvaev AN, Koyama C, Hira H.
High Transgene Expression by Lentiviral Vectors Causes Maldevelopment of Purkinje Cells in Vivo.
The Cerebellum 2010 Sep;9(3):291-302.
総説
平井宏和
News & Hot Paper Digest
「細胞膜に係留された神経ペプチド毒素によるシナプス伝達の遮断」
羊土社・実験医学 Vol.28 No.9, 1401-1402, 2010 June
2009
論文発表
Iizuka A, Takayama K, Torashima T, Yamasaki M, Koyama C, Mitsumura K, Watanabe M, Hirai H.
Neurobiology of Disease 2009 Sep;35(3):457-65. Epub 2009 Jun 30.
Torashima T, Iizuka A, Horiuchi H, Mitsumura K, Yamasaki M, Koyama C, Takayama K, IinoM, Watanabe M, Hirai H.
European Journal of Neuroscience 2009 Aug;30(3):355-65. Epub 2009 Jul 15
Oue M, Mitsumura K, Torashima T, Koyama C, Yamaguchi H, Furuya N, Hirai H.
Characterization of mutant mice that express polyglutamine in cerebellar Purkinje cells.
Brain Research 2009 Feb 19;1255:9-17.
Shiba K, Torashima T, Hirai H, Ogawa K, Akhter N, Nakajima K, Kinuya S, Mori H.
Potential usefulness of D(2)R reporter gene imaging by IBF as gene therapy monitoring for cerebellar neurodegenerative diseases.
Journal of Cerebral Blood Flow & Metabolism 2009 Feb;29(2):434-40.
Kobayashi T, Hirai H, Iino M, Fuse I, Mitsumura K, Washiyama K, Kasai S, Ikeda K.
Neuropharmacology 2009 Feb;56(2):499-506.
総説
平井 宏和
【特集 遺伝子－脳回路－行動】
脳の遺伝子治療の可能性と展望
生体の科学. Vol.60 No.1, 23-30, 2009
平井宏和
News&Hot Paper Digest
「マイクロRNAが脊髄小脳変性症１型の病態に関与」
羊土社・実験医学. Vol.3, 104-405, 2009
平井宏和(著書、分担執筆）
V. 生殖医学 A. 基礎分野での進歩
「最近の知見からみるオキシトシンと母性の新しい概念」
Annual Review 糖尿病・代謝・内分泌. 中外医学社, 196-201, 2009
2008
論文発表
Sato T, Torashima T, Sugihara K, Hirai H, Asano M, Yoshioka K.
Molecular and Cellular Neuroscience 2008 Dec;39(4):569-78. Epub 2008 Aug 30.
Takayama K, Torashima T, Horiuchi H, Hirai H
Neuroscience Letters 2008 Sep 26;443(1):7-11. Epub 2008 Jul 25.
Hirai H.
Progress in transduction of cerebellar Purkinje cells in vivo using viral vectors.
The Cerebellum 2008 7(3):273-8.
Han L, Suda M, Tsuzuki K, Wang R, Ohe Y, Hirai H, Watanabe T, Takeuchi T, Hosaka M.
Molecular Endocrinology 2008 Aug;22(8):1935-49. Epub 2008 May 15.
Torashima T, Koyama C, Iizuka A, Mitsumura K, Takayama K, Yanagi S, Oue M, Yamaguchi H, Hirai H.
Lentivector-mediated rescue from cerebellar ataxia in a mouse model of spinocerebellar ataxia.
EMBO Reports 2008 Apr;9(4):393-9. Epub 2008 Mar 14.
総説
平井 宏和
脊髄小脳変性症 SCDマウスの運動障害を遺伝子治療で改善
難病と在宅ケア Vol.14 No.2(5月号), 43-46, 2008
2007
論文発表
Torashima T, Koyama C, Higashida H, Hirai H.
Production of neuron-preferential lentiviral vectors.
Nature Protocols Epub 2007 Feb 14.
Nakamura K, Hirai H, Torashima T, Miyazaki T, Tsurui H, Xin Y, Ohtsuji M, Shun Lin Q, Tsukamoto K, Nishimura H, Ono M, Watanabe M and Hirose S.
CD3 and immunoglobulin G fc receptor regulate cerebellar functions.
Molecular and Cell Biology 2007 Jul;27(14):5128-34, 2007.
Jin D*, Liu HX*, Hirai H*, Torashima T, Nagai T, Lopatina O, Shnayder NA, Yamada K, Noda M, Seike T, Fujita K, Takasawa S, Yokoyama S, Koizumi K, Shiraishi Y, Tanaka S, Hashii M, Yoshihara T, Higashida K, Islam MS, Yamada N, Hayashi K, Noguchi N, Kato I, Okamoto H, Matsushima A, Salmina A, Munesue T, Shimizu N, Mochida S, Asano M and Higashida H. （*equally contributed)
CD38 is critical for social behaviour by regulating oxytocin secretion.
Nature 2007 Mar 1;446(7131):41-5, 2007.
Kakegawa W, Miyazaki T, Hirai H, Motohashi J, Mishima M, Watanabe M, Yuzaki M.
Journal of Physiology 2007 Mar 15;579(Pt 3):729-35, 2007.
総説
平井 宏和、東田陽博
｢子育て」「他者の認識と記憶」に必要な膜タンパク質ＣＤ38
羊土社・実験医学. Vol.25 No.11(7月号) 1707-1710, 2007
平井 宏和
グルタミン酸受容体リン酸化と運動学習制御
クバプロ・ブレインサイエンス レビュー2007, 123-140
2006
論文発表
Hisatsune C, Kuroda Y, Akagi T, Torashima T, Hirai H, Hashikawa T, Inoue T, Mikoshiba K
Inositol 1, 4, 5-Trisphosphate Receptor Type 1 in Granule Cells, not in Purkinje Cells, Regulates the Dendritic Morphology of Purkinje Cells through BDNF Production.
J. Neurosci. 18;26(42):10916-10924, 2006
Torashima T, Yamada N, Itoh M, Yamamoto A, Hirai H.
Exposure of lentiviral vectors to subneutral pH shifts the tropism from Purkinje cell to Bergmann glia.
Eur .J. Neurosci. Jul 24:371-380, 2006
Torashima T, Okoyama S, Nishizaki T, Hirai H.
In vivo transduction of murine cerebellar Purkinje cells by HIV-derived lentiviral vectors.
Brain Res. Apr 12;1082(1):11-22, 2006
Qin Q, Inatome R, Hotta A, Kojima M, Yamamura H, Hirai H, Yoshizawa T, Tanaka H, Fukami K, and Yanagi S.
A novel GTPase, CRAG, mediates PML-associated nuclear body formation and degradation of expanded polyglutamine protein.
J. Cell. Biol. 172:497-504, 2006
Takaturu Y., Takayasu Y., Iino M., Nikkuni O., Ueda Y., Tanaka K.,and Ozawa S.
Roles of glial glutamate transporters in shaping EPSCs at the climbing fiber-Purkinje cell synapses.
Neurosci. Res. 54:140-148, 2006
Takayasu Y., Iino M., Shimamoto K., Tanaka K. and Ozawa S.
Glial glutamate transporters maintain One-to-One relationship at the limbing fiber-Purkinje cell synapse by preventing glutamate spillover
J. Neurosci. 26: 6563-6572., 2006
Tsuzuki K, Tricoire L, Gibelin N, Bourout G, Rossier J, Lambolez B.
Calcium dependence of aequorin bioluminescence dissected by random mutagenesis.
Proc. Natl. Acad. Sci. U.S.A 103: 9500-9505, 2006
総説
平井 宏和
神経細胞選択的なHIV由来レンチウィルスベクターの作製法
羊土社・実験医学 Vol.24 No.19(12月号) 2006, 2997-3001
平井 宏和
小脳シナプス形成とシナプス可塑性を制御する分子・細胞メカニズム
羊土社・実験医学 Vol.24 No.15(増刊) 2006, 192(2402)
