Mieda T, Suto N, Iizuka A, Matsuura S, Iizuka H, Takagishi K, Nakamura K, Hirai H.
Mesenchymal stem cells attenuate peripheral neuronal degeneration in spinocerebellar ataxia type 1 knockin mice.
J Neurosci Res. 2016 Mar;94(3):246-52. Epub 2015 Dec 28.

Ageta-Ishihara N, Yamazaki M, Konno K, Nakayama H, Abe M, Hashimoto K, Nishioka T, Kaibuchi K, Hattori S, Miyakawa T, Tanaka K, Huda F, Hirai H, Hashimoto K, Watanabe M, Sakimura K, Kinoshita M.
A CDC42EP4/septin-based perisynaptic glial scaffold facilitates glutamate clearance.
Nat Commun. 2015 Dec 10;6:10090.

Nóbrega C, Carmo-Silva S, Albuquerque D, Vasconcelos-Ferreira A, Vijayakumar UG, Mendonça L, Hirai H, Pereira de Almeida L.
Re-establishing ataxin-2 downregulates translation of mutant ataxin-3 and alleviates Machado-Joseph disease.
Brain 2015 Dec;138(Pt 12):3537-54.

Duarte-Neves J, Gonçalves N, Cunha-Santos J, Simões AT, den Dunnen WF, Hirai H, Kügler S, Cavadas C, Pereira de Almeida L.
Neuropeptide Y mitigates neuropathology and motor deficits in mouse models of Machado-Joseph disease.
Hum Mol Genet 2015 Oct 1;24(19):5451-63.

Iizuka A, Matsuzaki Y, Konno A, Hirai H.
Plasticity of the developmentally arrested staggerer cerebellum in response to exogenous RORα.
Brain Structure and Function 2016 Jul;221(6):2879-89. Epub 2015 Jun 30.

Kusakari S, Saitow F, Ago Y, Shibasaki K, Sato-Hashimoto M, Matsuzaki Y, Kotani T, Murata Y, Hirai H, Matsuda T, Suzuki H, Matozaki T, Ohnishi H.
Shp2 in forebrain neurons regulates synaptic plasticity, locomotion, and memory formation in mice.
Molecular and Cellular Biology 2015 May 1;35(9):1557-72.

Iizuka A, Nakamura K, Hirai H.
Long-term oral administration of the NMDA receptor antagonist memantine extends life span in spinocerebellar ataxia type 1 knock-in mice.
Neurosci Lett 2015 Apr 10;592:37-41.

Nakamura K, Mieda T, Suto N, Matsuura S, Hirai H.
Mesenchymal Stem Cells as a Potential Therapeutic Tool for Spinocerebellar Ataxia.
Cerebellum 2015 Apr;14(2):165-70.

Mendonça LS, Nóbrega C, Hirai H, Kaspar BK, Pereira de Almeida L
Transplantation of cerebellar neural stem cells improves motor coordination and neuropathology in Machado-Joseph disease mice.
Brain 2015 Feb;138(Pt 2):320-35.

Uesaka N, Uchigashima M, Mikuni T, Hirai H, Watanabe M, Kano M.
Retrograde Signaling for Climbing Fiber Synapse Elimination.
Cerebellum 2015 Feb;14(1):4-7.

Takahashi H, Adachi N, Shirafuji T, Danno S, Ueyama T, Vendruscolo M, Shuvaev AN, Sugimoto T, Seki T, Hamada D, Irie K, Hirai H, Sakai N, Saito N.
Identification and characterization of PKCγ, a kinase associated with SCA14, as an amyloidogenic protein.
Human Molecular Genetics 2015 Jan 15;24(2):525-39.

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脊髄小脳変性症・多系統萎縮症に対する幹細胞研究の現状
脊髄小脳変性症・多系統萎縮症 Q&A 172 平成27年3月発行