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Irie T, Matsuzaki Y, Sekino Y, Hirai H.
Kv3.3 channels harboring a mutation of spinocerebellar ataxia type 13 alterexcitability and induce cell death in cultured cerebellar Purkinje cells.
The Journal of Physiology 2014 Jan 1;592(Pt 1):229-47.
Konno A, Shuvaev AN, Miyake N, Miyake K, Iizuka A, Matsuura S, Huda F,
Nakamura K, Yanagi S, Shimada T, Hirai H.
Mutant Ataxin-3 with an Abnormally Expanded Polyglutamine Chain Disrupts Dendritic Development and Metabotropic Glutamate Receptor Signaling in Mouse Cerebellar Purkinje Cells.
The Cerebellum 2014 Feb;13(1):29-41.
Matsuzaki Y, Oue M, Hirai H.
Generation of a neurodegenerative disease mouse model using lentiviral vectors carrying an enhanced synapsin I promoter.
The Journal of Neuroscience Methods 2014 Feb 15;223:133-43.
Matsuura S, Shuvaev AN, Iizuka A, Nakamura K, Hirai H.
Mesenchymal Stem Cells Ameliorate Cerebellar Pathology in a Mouse Model of Spinocerebellar Ataxia Type 1.
The Cerebellum 2014 Jun;13(3):323-30.
Okonogi N, Nakamura K, Suzuki Y. Suto N. Suzue K. Kaminama T. Nakano T.
Hirai H.
Cranial irradiation induces bone marrow-derived microglia in adult mouse
brain tissue.
Journal of Radiation Research 2014 Jul;55(4):713-9.
Uesaka N, Uchigashima M, Mikuni T, Nakazawa T, Nakao H, Hirai H, Aiba A, Watanabe M, Kano M.
Retrograde semaphorin signaling regulates synapse elimination in the developing
mouse brain.
Science 2014 May 30;344(6187):1020-3.
Huda F, Konno A. Matsuzaki Y. Goenawan H. Miyake K. Shimada T and Hirai
H.
Distinct transduction profiles in the CNS via three injection routes of
AAV9 and the application to generation of a neurodegenerative mouse model.
Molecular Therapy-Methods & Clinical Development 2014 Aug 6.
Saida H, Matsuzaki Y, Takayama K, Iizuka A, Konno A, Yanagi S, Hirai H.
One-year follow-up of transgene expression by integrase-defective lentiviral
vectors and their therapeutic potential in spinocerebellar ataxia model
mice.
Gene Therapy 2014 Sep;21(9):820-7.
Takahashi H, Adachi N, Shirafuji T, Danno S, Ueyama T, Vendruscolo M, Shuvaev AN, Sugimoto T, Seki T, Hamada D, Irie K, Hirai H, Sakai N, Saito N.
Identification and characterization of PKCγ, a kinase associated with SCA14, as an amyloidogenic protein.
Human Molecular Genetics 2014 Sep 12.
Yoshihara S, Takahashi H, Nishimura N, Kinoshita M, Asahina R, Kitsuki
M. Tatsumi K, Furukawa-Hibi Y, Hirai H, Nagai T, Yamada K, Tsuboi A.
Npas4 regulates Mdm2 and thus Dcx in experience-dependent dendritic spine development of newborn olfactory bulb interneurons.
Cell Reports 2014 Aug 7;8(3):843-57.
Nakamura K, Mieda T, Suto N, Matsuura S, Hirai H.
Mesenchymal Stem Cells as a Potential Therapeutic Tool for Spinocerebellar
Ataxia.
Cerebellum 2014 Oct 4. [Epub ahead of print]
Uesaka N, Uchigashima M, Mikuni T, Hirai H, Watanabe M, Kano M.
Retrograde Signaling for Climbing Fiber Synapse Elimination.
Cerebellum 2014 Oct 23. [Epub ahead of print]
Nóbrega C, Nascimento-Ferreira I, Onofre I, Albuquerque D, Hirai H, Déglon N, de Almeida LP.
Silencing mutant ataxin-3 rescues motor deficits and neuropathology in Machado-Joseph disease transgenic mice.
PLoS One 2013;8(1):e52396.
Takechi Y, Mieda T, Iizuka A, Toya S, Suto N, Takagishi K, Nakazato Y,
Nakamura K, Hirai H.
Impairment of spinal motor neurons in spinocerebellar ataxia type 1-knock-in mice.
Neuroscience Letters 2013 Feb 22;535:67-72.
Liu HX, Lopatina O, Higashida C, Fujimoto H, Akther S, Inzhutova A, Liang
M, Zhong J, Tsuji T, Yoshihara T, Sumi K, Ishiyama M, Ma WJ, Ozaki M, Yagitani
S, Yokoyama S, Mukaida N, Sakurai T, Hori O, Yoshioka K, Hirao A, Kato
Y, Ishihara K, Kato I, Okamoto H, Cherepanov SM, Salmina AB, Hirai H, Asano M, Brown DA, Nagano I, Higashida H
Displays of paternal mouse pup retrieval following communicative interaction
with maternal mates.
Nature Communications 2013;4:1346.
Yamaura H. Hirai H, Yanagihara D.
Postural dysfunction in a transgenic mouse model of spinocerebellar ataxia
type 3.
Neuroscience 2013 Jul 23;243:126-35.
Mikuni T, Uesaka N, Okuno H, Hirai H, Deisseroth K, Bito H, Kano M.
Arc/Arg3.1 is a postsynaptic mediator of activity-dependent synapse elimination
in the developing cerebellum.
Neuron 2013 Jun 19;78(6):1024-35.
Nascimento-Ferreira I, Nóbrega C, Vasconcelos-Ferreira A, Onofre I, Albuquerque
D, Aveleira C, Hirai H, Déglon N, Pereira de Almeida L.
Beclin 1 mitigates motor and neuropathological deficits in genetic mouse
models of Machado-Joseph disease.
Brain 2013 Jul;136(Pt 7):2173-88.
Akther S, Korshnova N, Zhong J, Liang M, Cherepanov SM, Lopatina O, Komleva
YK, Salmina AB, Nishimura T, Fakhrul AA, Hirai H, Kato I, Yamamoto Y, Takasawa S, Okamoto H, Higashida H.
CD38 in the nucleus accumbens and oxytocin are related to paternal behavior
in mice.
Molecular Brain 2013 Sep 23;6(1):41.
Miki T, Hirai H, Takahashi T.
Activity-dependent neurotrophin signaling underlies developmental switch of Ca2+ channel subtypes mediating neurotransmitter release.
The Journal of Neuroscience 2013 Nov 27;33(48):18755-63.
Jin D, Muramatsu SI, Shimizu N, Yokoyama S, Hirai H, Yamada K, Liu HX, Higashida C, Hashii M, Higashida A, Asano M, Ohkuma S, Higashida H.
Dopamine release via the vacuolar ATPase V0 sector c-subunit, confirmed in N18 neuroblastoma cells, results in behavioral recovery in hemiparkinsonian mice.
Neurochemistry International 2012 Nov;61(6):907-12
Yoshihara SI, Takahashi H, Nishimura N, Naritsuka H, Shirao T, Hirai H, Yoshihara Y, Mori K, Stern PL, Tsuboi A.
5T4 Glycoprotein Regulates the SensoryInput-Dependent Development of a Specific Subtype of Newborn Interneurons inthe Mouse Olfactory Bulb.
Journal of Neuroscience 2012 Feb 8;32(6):2217-2226.
Hirai H.
Basic research on cerebellar gene therapy using lentiviral vectors.
The Cerebellum 2012 Jun 11(2): 443-5
Uesaka N. Mikuni T. Hashimoto K. Hirai H. Sakimura K. Kano M.
Organotypic Coculture Preparation for the Study of Developmental SynapseElimination in Mammalian Brain.
Journal of Neuroscience 2012 Aug 22; 32(34): 11657-11670
Goenawan H. Hirai H.
Modulation of lentiviral vector tropism in cerebellar Purkinje cells in vivo by a lysosomal cysteine protease cathepsin K.
Journal of NeuroVirology 2012 Dec;18(6):521-31
Oue M, Handa H, Matsuzaki Y, Suzue K, Murakami H, Hirai H.
The murine stem cell virus promoter drives correlated transgene expression
in the leukocytes and cerebellar Purkinje cells of transgenic mice.
PLoS One 2012;7(11):e51015.
Mitsumura K, Hosoi N, Furuya N, Hirai H.
Disruption of metabotropic glutamate receptor signalling is a major defect at cerebellar parallel fibre-Purkinje cell synapses in staggerer mutant mice.
2011 May 9; 589:3191-3209. Epub 2011 Jul 1
Shuvaev AN, Horiuchi H, Seki T, Goenawan H, Irie T, Iizuka A, Sakai N, Hirai H.
Mutant PKC{gamma} in spinocerebellar ataxia type 14 disrupts synapse elimination and long-term depression in Purkinje cells in vivo.
The Journal of Neuroscience 2011 Oct 5;31(40):14324-34.
Hirai H.
Basic research on cerebellar gene therapy using lentiviral vectors.
The Cerebellum 2011 Nov 26. [Epub ahead of print]
Sasaki J, Kofuji S, Itoh R, Momiyama T, Takayama K, Murakami H, Chida S, Tsuya Y, Takasuga S, Eguchi S, Asanuma K, Horie Y, Miura K, Davies EM, Mitchell C, Yamazaki M, Hirai H, Takenawa T, Suzuki A, Sasaki T.
The PtdIns(3,4)P(2) phosphatase INPP4A is a suppressor of excitotoxic neuronal death.
Nature 2010 May 27;465(7297):497-501. Epub 2010 May 12.
Munesue T, Yokoyama S, Nakamura K, Anitha A, Yamada K, Hayashi K, Asaka T, Liu HX, Jin D, Koizumi K, Islam MS, Huang JJ, Ma WJ, Kim UH, Kim SJ, Park K, Kim D, Kikuchi M, Ono Y, Nakatani H, Suda S, Miyachi T, Hirai H, Salmina A, Pichugina YA, Soumarokov AA, Takei N, Mori N, Tsujii M, Sugiyama T, Yagi K, Yamagishi M, Sasaki T, Yamasue H, Kato N, Hashimoto R, Taniike M, Hayashi Y, Hamada J, Suzuki S, Ooi A, Noda M, Kamiyama Y, Kido MA, Lopatina O, Hashii M, Amina S, Malavasi F, Huang EJ, Zhang J, Shimizu N, Yoshikawa T, Matsushima A, Minabe Y, Higashida H.
Two genetic variants of CD38 in subjects with autism spectrum disorder and controls.
Neuroscience Research 2010 Jun;67(2):181-91. Epub 2010 May 1
Sawada Y, Kajiwara G, Iizuka A, Takayama K, Shuvaev AN, Koyama C, Hirai H.
High Transgene Expression by Lentiviral Vectors Causes Maldevelopment of Purkinje Cells in Vivo.
The Cerebellum 2010 Sep;9(3):291-302.
Iizuka A, Takayama K, Torashima T, Yamasaki M, Koyama C, Mitsumura K, Watanabe M, Hirai H.
Lentiviral vector-mediated rescue of motor behavior in spontaneously occurring hereditary ataxic mice.
Neurobiology of Disease 2009 Sep;35(3):457-65. Epub 2009 Jun 30.
Torashima T, Iizuka A, Horiuchi H, Mitsumura K, Yamasaki M, Koyama C, Takayama K, IinoM, Watanabe M, Hirai H.
Rescue of abnormal phenotypes in delta2 glutamate receptor-deficient mice by the extracellular N-terminal and intracellular C-terminal domains of the delta2 glutamate receptor.
European Journal of Neuroscience 2009 Aug;30(3):355-65. Epub 2009 Jul 15
Oue M, Mitsumura K, Torashima T, Koyama C, Yamaguchi H, Furuya N, Hirai H.
Characterization of mutant mice that express polyglutamine in cerebellar Purkinje cells.
Brain Research 2009 Feb 19;1255:9-17.
Shiba K, Torashima T, Hirai H, Ogawa K, Akhter N, Nakajima K, Kinuya S, Mori H.
Potential usefulness of D(2)R reporter gene imaging by IBF as gene therapy monitoring for cerebellar neurodegenerative diseases.
Journal of Cerebral Blood Flow & Metabolism 2009 Feb;29(2):434-40.
Kobayashi T, Hirai H, Iino M, Fuse I, Mitsumura K, Washiyama K, Kasai S, Ikeda K.
Inhibitory effects of the antiepileptic drug ethosuximide on G protein-activated inwardly rectifying K+ channels.
Neuropharmacology 2009 Feb;56(2):499-506.
Sato T, Torashima T, Sugihara K, Hirai H, Asano M, Yoshioka K.
The scaffold protein JSAP1 regulatesproliferation and differentiation of cerebellar granule cell precursors bymodulating JNK signaling.
Molecular and Cellular Neuroscience 2008 Dec;39(4):569-78. Epub 2008 Aug 30.
Takayama K, Torashima T, Horiuchi H, Hirai H
Purkinje-cell-preferential transduction by lentiviral vectors with the murine stem cell virus promoter.
Neuroscience Letters 2008 Sep 26;443(1):7-11. Epub 2008 Jul 25.
Hirai H.
Progress in transduction of cerebellar Purkinje cells in vivo using viral vectors.
The Cerebellum 2008 7(3):273-8.
Han L, Suda M, Tsuzuki K, Wang R, Ohe Y, Hirai H, Watanabe T, Takeuchi T, Hosaka M.
A large form of secretogranin III functions as a sorting receptor for chromogranin A aggregates in PC12 cells.
Molecular Endocrinology 2008 Aug;22(8):1935-49. Epub 2008 May 15.
Torashima T, Koyama C, Iizuka A, Mitsumura K, Takayama K, Yanagi S, Oue M, Yamaguchi H, Hirai H.
Lentivector-mediated rescue from cerebellar ataxia in a mouse model of spinocerebellar ataxia.
EMBO Reports 2008 Apr;9(4):393-9. Epub 2008 Mar 14.
Torashima T, Koyama C, Higashida H, Hirai H.
Production of neuron-preferential lentiviral vectors.
Nature Protocols Epub 2007 Feb 14.
Nakamura K, Hirai H, Torashima T, Miyazaki T, Tsurui H, Xin Y, Ohtsuji M, Shun Lin Q, Tsukamoto K, Nishimura H, Ono M, Watanabe M and Hirose S.
CD3 and immunoglobulin G fc receptor regulate cerebellar functions.
Molecular and Cell Biology 2007 Jul;27(14):5128-34, 2007.
Jin D*, Liu HX*, Hirai H*, Torashima T, Nagai T, Lopatina O, Shnayder NA, Yamada K, Noda M, Seike T, Fujita K, Takasawa S, Yokoyama S, Koizumi K, Shiraishi Y, Tanaka S, Hashii M, Yoshihara T, Higashida K, Islam MS, Yamada N, Hayashi K, Noguchi N, Kato I, Okamoto H, Matsushima A, Salmina A, Munesue T, Shimizu N, Mochida S, Asano M and Higashida H. （*equally contributed)
CD38 is critical for social behaviour by regulating oxytocin secretion.
Nature 2007 Mar 1;446(7131):41-5, 2007.
Kakegawa W, Miyazaki T, Hirai H, Motohashi J, Mishima M, Watanabe M, Yuzaki M.
Ca2+ permeability of the channel pore is not essential
for the {delta}2 glutamate receptor to regulate synaptic plasticity
and motor coordination.
Journal of Physiology 2007 Mar 15;579(Pt 3):729-35, 2007.
Hisatsune C, Kuroda Y, Akagi T, Torashima T, Hirai H, Hashikawa T, Inoue T, Mikoshiba K
Inositol 1, 4, 5-Trisphosphate Receptor Type 1 in Granule Cells, not in Purkinje Cells, Regulates the Dendritic Morphology of Purkinje Cells through BDNF Production.
J. Neurosci. 18;26(42):10916-10924, 2006
Torashima T, Yamada N, Itoh M, Yamamoto A, Hirai H.
Exposure of lentiviral vectors to subneutral pH shifts the tropism from Purkinje cell to Bergmann glia.
Eur .J. Neurosci. Jul 24:371-380, 2006
Torashima T, Okoyama S, Nishizaki T, Hirai H.
In vivo transduction of murine cerebellar Purkinje cells by HIV-derived lentiviral vectors.
Brain Res. Apr 12;1082(1):11-22, 2006
Qin Q, Inatome R, Hotta A, Kojima M, Yamamura H, Hirai H, Yoshizawa T, Tanaka H, Fukami K, and Yanagi S.
A novel GTPase, CRAG, mediates PML-associated nuclear body formation and degradation of
expanded polyglutamine protein.
J. Cell. Biol. 172:497-504, 2006
Takaturu Y., Takayasu Y., Iino M., Nikkuni O., Ueda Y., Tanaka K.,and Ozawa S.
Roles of glial glutamate transporters in shaping EPSCs at the climbing fiber-Purkinje cell synapses.
Neurosci. Res. 54:140-148, 2006
Takayasu Y., Iino M., Shimamoto K., Tanaka K. and Ozawa S.
Glial glutamate transporters maintain One-to-One relationship at the limbing fiber-Purkinje cell synapse by preventing glutamate spillover
J. Neurosci. 26: 6563-6572., 2006
Tsuzuki K, Tricoire L, Gibelin N, Bourout G, Rossier J, Lambolez B.
Calcium dependence of aequorin bioluminescence dissected by random mutagenesis.
Proc. Natl. Acad. Sci. U.S.A 103: 9500-9505, 2006
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