PUBLICATIONS

2019

Matsuzaki Y, Tanaka M, Hakoda S, Masuda T, Miyata R, Konno A, Hirai H
Neurotropic Properties of AAV-PHP.B Are Shared among Diverse Inbred Strains of Mice
Mol Ther. 2019 Feb 28. [Epub ahead of print]

Cendelin J, Buffo A, Hirai H, Magrassi L, Mitoma H, Sherrard R, Vozeh F, Manto M
Task Force Paper On Cerebellar Transplantation: Are We Ready to Treat Cerebellar Disorders with Cell Therapy?
Cerebellum. 2019 Jan 3. [Epub ahead of print]

Watanave M, Hoshino C, Konno A, Fukuzaki Y, Matsuzaki Y, Ishitani T, Hirai H
Pharmacological enhancement of retinoid-related orphan receptor α function mitigates spinocerebellar ataxia type 3 pathology.
Neurobiol Dis. 2019 Jan;121:263-273. Epub 2018 Oct 19.

2018

Watanave M, Matsuzaki Y, Nakajima Y, Ozawa A, Yamada M, Hirai H
Contribution of Thyrotropin-Releasing Hormone to Cerebellar Long-Term Depression and Motor Learning.
Front Cell Neurosci. 2018 Dec 12.

Seki T, Sato M, Konno A, Hirai H, Kurauchi Y, Hisatsune A, Katsuki H.
d-Cysteine promotes dendritic development in primary cultured cerebellar Purkinje cells via hydrogen sulfide production.
Mol Cell Neurosci. 2018 Dec;93:36-47. Epub 2018 Oct 19.

Shinohara Y, Konno A, Nitta K, Matsuzaki Y, Yasui H, Suwa J, Hiromura K, Hirai H.
Effects of Neutralizing Antibody Production on AAV-PHP.B-Mediated Transduction of the Mouse Central Nervous System.
Mol Neurobiol. 2018 Oct 5. [Epub ahead of print]

Seki T, Sato M, Kibe Y, Ohta T, Oshima M, Konno A, Hirai H, Kurauchi Y, Hisatsune A, Katsuki H.
Lysosomal dysfunction and early glial activation are involved in the pathogenesis of spinocerebellar ataxia type 21 caused by mutant transmembrane protein 240.
Neurobiol Dis. 2018 Sep 2. pii: S0969-9961(18)30519-9.

Gaffield MA, Rowan MJM, Amat SB, Hirai H, Christie JM.
Inhibition gates supralinear Ca2+ signaling in Purkinje cell dendrites during practiced movements.
Elife. 2018 Aug 17;7. pii: e36246.

Hirai H and Kano M.
Type 1 metabotropic glutamate receptor and its signaling molecules as therapeutic targets for the treatment of cerebellar disorders.
Curr Opin Pharmacol. 2018 Feb;38:51-58.

Hirai H.
Protein Kinase C in the Cerebellum: Its Significance and Remaining Conundrums.
Cerebellum. 2018 Feb;17(1):23-27.

Ogawa Y, Kakumoto K, Yoshida T, Kuwako KI, Miyazaki T, Yamaguchi J, Konno A, Hata J, Uchiyama Y, Hirai H, Watanabe M, Darnell RB, Okano H, Okano HJ
Elavl3 is essential for the maintenance of Purkinje neuron axons.
Sci Rep. 2018 Feb 9;8(1):2722.

Matsuzaki Y, Konno A, Mochizuki R, Shinohara Y, Nitta K, Okada Y, Hirai H
Intravenous administration of the adeno-associated virus-PHP.B capsid fails to upregulate transduction efficiency in the marmoset brain.
Neurosci Lett. 2018 Feb 5;665:182-188. Epub 2017 Nov 24.

2017

Takahashi N, Shuvaev AN, Konno A, Matsuzaki Y, Watanave M, Hirai H.
Regulatory connection between the expression level of classical protein kinase C and pruning of climbing fibers from cerebellar Purkinje cells.
J Neurochem. 2017 Dec;143(6):660-670. Epub 2017 Nov 29.

Nitta K, Matsuzaki Y, Konno A, Hirai H
Minimal Purkinje Cell-Specific PCP2/L7 Promoter Virally Available for Rodents and Non-human Primates.
Mol Ther Methods Clin Dev. 2017 Jul 27;6:159-170.

Harada K, Ito M, Wang X, Tanaka M, Wongso D, Konno A, Hirai H, Hirase H, Tsuboi T, Kitaguchi T.
Red fluorescent protein-based cAMP indicator applicable to optogenetics and in vivo imaging.
Scientific Reports. 2017 Aug 4;7(1):7351

Hattori T, Kaji M, Ishii H, Jureepon R, Takarada-Iemata M, Minh Ta H, Manh Le T, Konno A, Hirai H, Shiraishi Y, Ozaki N, Yamamoto Y, Okamoto H, Yokoyama S, Higashida H, Kitao Y, Hori O.
CD38 positively regulates postnatal development of astrocytes cell-autonomously and oligodendrocytes non-cell-autonomously.
Glia. 2017 Jun;65(6):974-989. Epub 2017 Mar 13.

Shinohara Y, Ohtani T, Konno A, Hirai H
Viral Vector-Based Evaluation of Regulatory Regions in the Neuron-Specific Enolase (NSE) Promoter in Mouse Cerebellum In Vivo.
Cerebellum. 2017 Dec;16(5-6):913-922.

Matsuzaki Y, Konno A, Mukai R, Honda F, Hirato M, Yoshimoto Y, Hirai H.
Transduction Profile of the Marmoset Central Nervous System Using Adeno-Associated Virus Serotype 9 Vectors.
Molecular Neurobiology. 2017 Apr;54(3):1745-1758. Epub 2016 Feb 16.

Gonçalves N, Simões AT, Prediger RD, Hirai H, Cunha RA, Pereira de Almeida L
Caffeine alleviates progressive motor deficits in a transgenic mouse model of spinocerebellar ataxia.
Ann Neurol. 2017 Mar;81(3):407-418. Epub 2017 Feb 17.

Shuvaev AN, Hosoi N, Sato Y, Yanagihara D, Hirai H
Progressive impairment of cerebellar mGluR signalling and its therapeutic potential for cerebellar ataxia in spinocerebellar ataxia type 1 model mice.
Journal of Physiology. 2017 Jan 1;595(1):141-164. Epub 2016 Sep 15.

2016

• Arsenault J, Gholizadeh S, Niibori Y, Pacey LK, Halder SK, Koxhioni E, Konno A, Hirai H, Hampson DR.
  FMRP Expression Levels in Mouse CNS Neurons Determine Behavioral Phenotype.
  Human Gene Therapy. 2016 Dec;27(12):982-996.
• Ito E, Tomaru Y, Iizuka A, Hirai H, Kato T.
  Adaptive Local Thresholding for Co-Localization Detection in Multi-Channel Fluorescence Microscopic Images.
  IEICE Transactions on Information and Systems. 2016 Nov 1;99(11):2851-2855.
• Huda F, Fan Y, Suzuki M, Konno A, Matsuzaki Y, Takahashi N, Chan JK, Hirai H.
  Fusion of Human Fetal Mesenchymal Stem Cells with “Degenerating” Cerebellar Neurons in Spinocerebellar Ataxia Type 1 Model Mice.
  PLoS One. 2016 Nov 1;11(11):e0164202.
• Shinohara Y, Konno A, Takahashi N, Matsuzaki Y, Kishi S, Hirai H.
  Viral Vector-Based Dissection of Marmoset GFAP Promoter in Mouse and Marmoset Brains.
  PLoS One. 2016 Aug 29;11(8):e0162023.
• Takahashi H, Ogawa Y, Yoshihara S, Asahina R, Kinoshita M, Kitano T, Kitsuki M, Tatsumi K, Okuda M, Tatsumi K, Wanaka A, Hirai H, Stern PL, Tsuboi A.
  A Subtype of Olfactory Bulb Interneurons Is Required for Odor Detection and Discrimination Behaviors.
  Journal of Neuroscience. 2016 Aug 3;36(31):8210-27.
• Sato M, Seki T, Konno A, Hirai H, Kurauchi Y, Hisatsune A, Katsuki H.
  Fluorescent-based evaluation of chaperone-mediated autophagy and microautophagy activities in cultured cells.
  Genes Cells. 2016 Jul 5. [Epub ahead of print]
• Sawada Y, Konno A, Nagaoka J, Hirai H.
  Inflammation-induced reversible switch of the neuron-specific enolase promoter from Purkinje neurons to Bergmann glia.
  Sci Rep. 2016 Jun 13;6:27758.
• Yanai T, Kurosawa A, Nikaido Y, Nakajima N, Saito T, Osada H, Konno A, Hirai H, Takeda S.
  Identification and molecular docking studies for novel inverse agonists of SREB, super conserved receptor expressed in brain.
  Genes Cells. 2016 May 17. [Epub ahead of print]
• Suto N, Mieda T, Iizuka A, Nakamura K, Hirai H.
  Morphological and Functional Attenuation of Degeneration of Peripheral Neurons by Mesenchymal Stem Cell-Conditioned Medium in Spinocerebellar Ataxia Type 1-Knock-in Mice.
  CNS Neurosci Ther. 2016 Aug;22(8):670-6. Epub 2016 May 3.
• Monai H, Ohkura M, Tanaka M, Oe Y, Konno A, Hirai H, Mikoshiba K, Itohara S, Nakai J, Iwai Y, Hirase H.
  Calcium imaging reveals glial involvement in transcranial direct current stimulation-induced plasticity in mouse brain.
  Nat Commun. 2016 Mar 22;7:11100.
• Conceição M, Mendonça L, Nóbrega C, Gomes C, Costa P, Hirai H, Moreira JN, Lima MC, Manjunath N, Pereira de Almeida L.
  Intravenous administration of brain-targeted stable nucleic acid lipid particles alleviates Machado-Joseph disease neurological phenotype.
  Biomaterials. 2016 Mar;82:124-37. Epub 2015 Dec 21.
• Matsuzaki Y, Konno A, Mukai R, Honda F, Hirato M, Yoshimoto Y, Hirai H.
  Transduction Profile of the Marmoset Central Nervous System Using Adeno-Associated Virus Serotype 9 Vectors.
  Mol Neurobiol. 2016 Feb 16. [Epub ahead of print]
• Conceição M, Mendonça L, Nóbrega C, Gomes C, Costa P, Hirai H, Moreira JN, Lima MC, Manjunath N, Pereira de Almeida L.
  Safety profile of the intravenous administration of brain-targeted stable nucleic acid lipid particles.
  Data Brief. 2016 Jan 20;6:700-5.

2015

• Mieda T, Suto N, Iizuka A, Matsuura S, Iizuka H, Takagishi K, Nakamura K, Hirai H.
  Mesenchymal stem cells attenuate peripheral neuronal degeneration in spinocerebellar ataxia type 1 knockin mice.
  J Neurosci Res. 2016 Mar;94(3):246-52. Epub 2015 Dec 28.
• Ageta-Ishihara N, Yamazaki M, Konno K, Nakayama H, Abe M, Hashimoto K, Nishioka T, Kaibuchi K, Hattori S, Miyakawa T, Tanaka K, Huda F, Hirai H, Hashimoto K, Watanabe M, Sakimura K, Kinoshita M.
  A CDC42EP4/septin-based perisynaptic glial scaffold facilitates glutamate clearance.
  Nat Commun. 2015 Dec 10;6:10090.
• Nóbrega C, Carmo-Silva S, Albuquerque D, Vasconcelos-Ferreira A, Vijayakumar UG, Mendonça L, Hirai H, Pereira de Almeida L.
  Re-establishing ataxin-2 downregulates translation of mutant ataxin-3 and alleviates Machado-Joseph disease.
  Brain. 2015 Dec;138(Pt 12):3537-54.
• Duarte-Neves J, Gonçalves N, Cunha-Santos J, Simões AT, den Dunnen WF, Hirai H, Kügler S, Cavadas C, Pereira de Almeida L.
  Neuropeptide Y mitigates neuropathology and motor deficits in mouse models of Machado-Joseph disease.
  Hum Mol Genet. 2015 Oct 1;24(19):5451-63.
• Iizuka A, Matsuzaki Y, Konno A, Hirai H.
  Plasticity of the developmentally arrested staggerer cerebellum in response to exogenous RORα.
  Brain Structure and Function. 2016 Jul;221(6):2879-89. Epub 2015 Jun 30.
• Kusakari S, Saitow F, Ago Y, Shibasaki K, Sato-Hashimoto M, Matsuzaki Y, Kotani T, Murata Y, Hirai H, Matsuda T, Suzuki H, Matozaki T, Ohnishi H.
  Shp2 in forebrain neurons regulates synaptic plasticity, locomotion, and memory formation in mice.
  Molecular and Cellular Biology 2015 May 1;35(9):1557-72.
• Nakamura K, Mieda T, Suto N, Matsuura S, Hirai H.
  Mesenchymal Stem Cells as a Potential Therapeutic Tool for Spinocerebellar Ataxia.
  Cerebellum 2015 Apr;14(2):165-70.
• Mendonça LS, Nóbrega C, Hirai H, Kaspar BK, Pereira de Almeida L
  Transplantation of cerebellar neural stem cells improves motor coordination and neuropathology in Machado-Joseph disease mice.
  Brain. 2015 Feb;138(Pt 2):320-35.
• Uesaka N, Uchigashima M, Mikuni T, Hirai H, Watanabe M, Kano M.
  Retrograde Signaling for Climbing Fiber Synapse Elimination.
  Cerebellum. 2015 Feb;14(1):4-7.
• Takahashi H, Adachi N, Shirafuji T, Danno S, Ueyama T, Vendruscolo M, Shuvaev AN, Sugimoto T, Seki T, Hamada D, Irie K, Hirai H, Sakai N, Saito N.
  Identification and characterization of PKCγ, a kinase associated with SCA14, as an amyloidogenic protein.
  Human Molecular Genetics. 2015 Jan 15;24(2):525-39.

2014

• Irie T, Matsuzaki Y, Sekino Y, Hirai H.
  Kv3.3 channels harboring a mutation of spinocerebellar ataxia type 13 alterexcitability and induce cell death in cultured cerebellar Purkinje cells.
  The Journal of Physiology 2014 Jan 1;592(Pt 1):229-47.
• Konno A, Shuvaev AN, Miyake N, Miyake K, Iizuka A, Matsuura S, Huda F, Nakamura K, Yanagi S, Shimada T, Hirai H.
  Mutant Ataxin-3 with an Abnormally Expanded Polyglutamine Chain Disrupts Dendritic Development and Metabotropic Glutamate Receptor Signaling in Mouse Cerebellar Purkinje Cells.
  The Cerebellum 2014 Feb;13(1):29-41.
• Matsuzaki Y, Oue M, Hirai H.
  Generation of a neurodegenerative disease mouse model using lentiviral vectors carrying an enhanced synapsin I promoter.
  The Journal of Neuroscience Methods 2014 Feb 15;223:133-43.
• Matsuura S, Shuvaev AN, Iizuka A, Nakamura K, Hirai H.
  Mesenchymal Stem Cells Ameliorate Cerebellar Pathology in a Mouse Model of Spinocerebellar Ataxia Type 1.
  The Cerebellum 2013 Nov 17. [Epub ahead of print]
• Okonogi N, Nakamura K, Suzuki Y, Suto N, Suzue K, Kaminama T, Nakano T, Hirai H.
  Cranial irradiation induces bone marrow-derived microglia in adult mouse brain tissue.
  Journal of Radiation Research 2014 Jul;55(4):713-9.
• Uesaka N, Uchigashima M, Mikuni T, Nakazawa T, Nakao H, Hirai H, Aiba A, Watanabe M, Kano M.
  Retrograde semaphorin signaling regulates synapse elimination in the developing mouse brain.
  Science 2014 May 30;344(6187):1020-3.
• Huda F, Konno A. Matsuzaki Y. Goenawan H. Miyake K. Shimada T and Hirai H.
  Distinct transduction profiles in the CNS via three injection routes of AAV9 and the application to generation of a neurodegenerative mouse model.
  Molecular Therapy-Methods & Clinical Development 2014 Aug 6.
• Saida H, Matsuzaki Y, Takayama K, Iizuka A, Konno A, Yanagi S, Hirai H.
  One-year follow-up of transgene expression by integrase-defective lentiviral vectors and their therapeutic potential in spinocerebellar ataxia model mice.
  Gene Therapy 2014 Sep;21(9):820-7.
• Yoshihara S, Takahashi H, Nishimura N, Kinoshita M, Asahina R, Kitsuki M. Tatsumi K, Furukawa-Hibi Y, Hirai H, Nagai T, Yamada K, Tsuboi A.
  Npas4 regulates Mdm2 and thus Dcx in experience-dependent dendritic spine development of newborn olfactory bulb interneurons.
  Cell Reports 2014 Aug 7;8(3):843-57.

2013

• Nóbrega C, Nascimento-Ferreira I, Onofre I, Albuquerque D, Hirai H, Déglon N, de Almeida LP.
  Silencing mutant ataxin-3 rescues motor deficits and neuropathology in Machado-Joseph disease transgenic mice.
  PLoS One 2013;8(1):e52396.
• Takechi Y, Mieda T, Iizuka A, Toya S, Suto N, Takagishi K, Nakazato Y, Nakamura K, Hirai H.
  Impairment of spinal motor neurons in spinocerebellar ataxia type 1-knock-in mice.
  Neuroscience Letters 2013 Feb 22;535:67-72
• Liu HX, Lopatina O, Higashida C, Fujimoto H, Akther S, Inzhutova A, Liang M, Zhong J, Tsuji T, Yoshihara T, Sumi K, Ishiyama M, Ma WJ, Ozaki M, Yagitani S, Yokoyama S, Mukaida N, Sakurai T, Hori O, Yoshioka K, Hirao A, Kato Y, Ishihara K, Kato I, Okamoto H, Cherepanov SM, Salmina AB, Hirai H, Asano M, Brown DA, Nagano I, Higashida H
  Displays of paternal mouse pup retrieval following communicative interaction with maternal mates
  Nature Communications 2013;4:1346
• Yamaura H, Hirai H, Yanagihara D.
  Postural dysfunction in a transgenic mouse model of spinocerebellar ataxia type 3.
  Neuroscience 2013 Jul 23;243:126-35.
• Mikuni T, Uesaka N, Okuno H, Hirai H, Deisseroth K, Bito H, Kano M.
  Arc/Arg3.1 is a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum.
  Neuron 2013 Jun 19;78(6):1024-35.
• Nascimento-Ferreira I, Nóbrega C, Vasconcelos-Ferreira A, Onofre I, Albuquerque D, Aveleira C, Hirai H, Déglon N, Pereira de Almeida L.
  Beclin 1 mitigates motor and neuropathological deficits in genetic mouse models of Machado-Joseph disease.
  Brain 2013 Jul;136(Pt 7):2173-88.
• Akther S, Korshnova N, Zhong J, Liang M, Cherepanov SM, Lopatina O, Komleva YK, Salmina AB, Nishimura T, Fakhrul AA, Hirai H, Kato I, Yamamoto Y, Takasawa S, Okamoto H, Higashida H.
  CD38 in the nucleus accumbens and oxytocin are related to paternal behavior in mice.
  Molecular Brain 2013 Sep 23;6(1):41.
• Miki T, Hirai H, Takahashi T.
  Activity-dependent neurotrophin signaling underlies developmental switch of Ca2+ channel subtypes mediating neurotransmitter release.
  The Journal of Neuroscience 2013 Nov 27;33(48):18755-63.

2012

• Jin D, Muramatsu SI, Shimizu N, Yokoyama S, Hirai H, Yamada K, Liu HX, Higashida C, Hashii M, Higashida A, Asano M, Ohkuma S, Higashida H.
  Dopamine release via the vacuolar ATPase V0 sector c-subunit, confirmed in N18 neuroblastoma cells, results in behavioral recovery in hemiparkinsonian mice.
  Neurochemistry International 2012 Nov;61(6):907-12.
• Yoshihara SI, Takahashi H, Nishimura N, Naritsuka H, Shirao T, Hirai H, Yoshihara Y, Mori K, Stern PL, Tsuboi A.
  5T4 Glycoprotein Regulates the Sensory Input-Dependent Development of a Specific Subtype of Newborn Interneurons in the Mouse Olfactory Bulb.
  Journal of Neuroscience 32(6):2217-2226, 2012
• Hirai H.
  Basic research on cerebellar gene therapy using lentiviral vectors.
  The Cerebellum 11(2):443-5, 2012
• Uesaka N. Mikuni T. Hashimoto K. Hirai H. Sakimura K. Kano M.
  Organotypic Coculture Preparation for the Study of Developmental SynapseElimination in Mammalian Brain.
  Journal of Neuroscience 32(34):11657-70, 2012
• Goenawan H, Hirai H.
  Modulation of lentiviral vector tropism in cerebellar Purkinje cells in vivo by a lysosomal cysteine protease cathepsin K.
  Journal of NeuroVirology 2012 Dec;18(6):521-31.
• Oue M, Handa H, Matsuzaki Y, Suzue K, Murakami H, Hirai H.
  The Murine Stem Cell Virus Promoter Drives Correlated Transgene Expression in the Leukocytes and Cerebellar Purkinje Cells of Transgenic Mice.
  PLoS ONE 7(11): e51015. doi:10.1371/journal.pone.0051015

2011

• Mitsumura K, Hosoi N, Furuya N, Hirai H.
  Disruption of metabotropic glutamate receptor signalling is a major defect at cerebellar parallel fibre-Purkinje cell synapses in staggerer mutant mice.
  The Journal of Physiology 589:3191-3209, 2011
• Shuvaev AN, Horiuchi H, Seki T, Goenawan H, Irie T, Iizuka A, Sakai N, Hirai H.
  Mutant PKC{gamma} in spinocerebellar ataxia type 14 disrupts synapse elimination and long-term depression in Purkinje cells in vivo.
  The Journal of Neuroscience 31(40):14324-34, 2011

2010

• Sasaki J, Kofuji S, Itoh R, Momiyama T, Takayama K, Murakami H, Chida S, Tsuya Y, Takasuga S, Eguchi S, Asanuma K, Horie Y, Miura K, Davies EM, Mitchell C, Yamazaki M, Hirai H, Takenawa T, Suzuki A, Sasaki T.
  The PtdIns(3,4)P(2) phosphatase INPP4A is a suppressor of excitotoxic neuronal death.
  Nature 465(7297):497-501, 2010
• Munesue T, Yokoyama S, Nakamura K, Anitha A, Yamada K, Hayashi K, Asaka T, Liu HX, Jin D, Koizumi K, Islam MS, Huang JJ, Ma WJ, Kim UH, Kim SJ, Park K, Kim D, Kikuchi M, Ono Y, Nakatani H, Suda S, Miyachi T, Hirai H, Salmina A, Pichugina YA, Soumarokov AA, Takei N, Mori N, Tsujii M, Sugiyama T, Yagi K, Yamagishi M, Sasaki T, Yamasue H, Kato N, Hashimoto R, Taniike M, Hayashi Y, Hamada J, Suzuki S, Ooi A, Noda M, Kamiyama Y, Kido MA, Lopatina O, Hashii M, Amina S, Malavasi F, Huang EJ, Zhang J, Shimizu N, Yoshikawa T, Matsushima A, Minabe Y, Higashida H.
  Two genetic variants of CD38 in subjects with autism spectrum disorder and controls.
  Neuroscience Research 67(2):181-91, 2010
• Sawada Y, Kajiwara G, Iizuka A, Takayama K, Shuvaev AN, Koyama C, Hirai H.
  High Transgene Expression by Lentiviral Vectors Causes Maldevelopment of Purkinje Cells in Vivo.
  The Cerebellum 9(3):291-302, 2010

2009

• Iizuka A, Takayama K, Torashima T, Yamasaki M, Koyama C, Mitsumura K, Watanabe M, Hirai H.
  Lentiviral vector-mediated rescue of motor behavior in spontaneously occurring hereditary ataxic mice.
  Neurobiology of Disease 35(3):457-65, 2009
• Torashima T, Iizuka A, Horiuchi H, Mitsumura K, Yamasaki M, Koyama C, Takayama K, IinoM, Watanabe M, Hirai H.
  Rescue of abnormal phenotypes in delta2 glutamate receptor-deficient mice by the extracellular N-terminal and intracellular C-terminal domains of the delta2 glutamate receptor.
  European Journal of Neuroscience 30(3):355-65, 2009
• Oue M, Mitsumura K, Torashima T, Koyama C, Yamaguchi H, Furuya N, Hirai H.
  Characterization of mutant mice that express polyglutamine in cerebellar Purkinje cells.
  Brain Research 1255:9-17, 2009
• Shiba K, Torashima T, Hirai H, Ogawa K, Akhter N, Nakajima K, Kinuya S, Mori H.
  Potential usefulness of D(2)R reporter gene imaging by IBF as gene therapy monitoring for cerebellar neurodegenerative diseases.
  Journal of Cerebral Blood Flow & Metabolism 29(2):434-40, 2009
• Kobayashi T, Hirai H, Iino M, Fuse I, Mitsumura K, Washiyama K, Kasai S, Ikeda K.
  Inhibitory effects of the antiepileptic drug ethosuximide on G protein-activated inwardly rectifying K+ channels.
  Neuropharmacology 56(2):499-506, 2009

2008

• Sato T, Torashima T, Sugihara K, Hirai H, Asano M, Yoshioka K.
  The scaffold protein JSAP1 regulates proliferation and differentiation of cerebellar granule cell precursors by modulating JNK signaling.
  Molecular and Cellular Neuroscience 39(4):569-78, 2008
• Takayama K, Torashima T, Horiuchi H, Hirai H
  Purkinje-cell-preferential transduction by lentiviral vectors with the murine stem cell virus promoter.
  Neuroscience Letters 443(1):7-11, 2008
• Hirai H.
  Progress in transduction of cerebellar Purkinje cells in vivo using viral vectors.
  The Cerebellum 7(3):273-8, 2008
• Han L, Suda M, Tsuzuki K, Wang R, Ohe Y, Hirai H, Watanabe T, Takeuchi T, Hosaka M.
  A large form of secretogranin III functions as a sorting receptor for chromogranin A aggregates in PC12 cells.
  Molecular Endocrinology 22(8):1935-49, 2008
• Torashima T, Koyama C, Iizuka A, Mitsumura K, Takayama K, Yanagi S, Oue M, Yamaguchi H, Hirai H.
  Lentivector-mediated rescue from cerebellar ataxia in a mouse model of spinocerebellar ataxia.
  EMBO Reports 9(4):393-9, 2008

2007

• Torashima T, Koyama C, Higashida H, Hirai H.
  Production of neuron-preferential lentiviral vectors.
  Protocol Exchange doi:10.1038/nprot.2007.89
  Published online 14 February 2007
• Nakamura K, Hirai H, Torashima T, Miyazaki T, Tsurui H, Xin Y, Ohtsuji M, Shun Lin Q, Tsukamoto K, Nishimura H, Ono M, Watanabe M and Hirose S.
  CD3 and immunoglobulin G fc receptor regulate cerebellar functions.
  Molecular and Cell Biology 27(14):5128-34, 2007.
• Jin D*, Liu HX*, Hirai H*, Torashima T, Nagai T, Lopatina O, Shnayder NA, Yamada K, Noda M, Seike T, Fujita K, Takasawa S, Yokoyama S, Koizumi K, Shiraishi Y, Tanaka S, Hashii M, Yoshihara T, Higashida K, Islam MS, Yamada N, Hayashi K, Noguchi N, Kato I, Okamoto H, Matsushima A, Salmina A, Munesue T, Shimizu N, Mochida S, Asano M and Higashida H.　（*equally contributed)
  CD38 is critical for social behaviour by regulating oxytocin secretion.
  Nature 446(7131):41-5, 2007
• Kakegawa W, Miyazaki T, Hirai H, Motohashi J, Mishima M, Watanabe M, Yuzaki M.
  Ca2+ permeability of the channel pore is not essential for the {delta}2 glutamate receptor to regulate synaptic plasticity and motor coordination.
  Journal of Physiology 579(Pt 3):729-35, 2007

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