RESEARCH INTERESTS

We are working to elucidate the pathophysiology of the cerebellum, primarily focusing on an incurable disease, spinocerebellar ataxia (SCA). Major research subjects are as follows

• Development of viral vector-based efficient and cell-type specific gene transfer/expression system
  AAV and lentiviral vectors

• Development of novel therapies against SCAs
  Gene therapy and stem cell therapy

• Elucidation of molecular mechanisms regulating the cerebellar development
  Dendritogenesis and synaptogenesis of Purkinje cells
• Generation and analysis of gene-modified animals

EXPERIMENTAL TECHNIQUES

Electrophysiology Patch clamp recording using slice or dissociated neuronal culture preparations	Calcium imaging
Production of high titer lentiviral and AAV vectors	Stem cell culture
Molecular biology	Protein chemistry
Immunohistochemistry / Immunocytochemistry	Behavioral experiment Rotarod, beam test etc.
Generation of gene-modified mice	Confocal microscopy

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