2024
論文 Articles
Matsuzaki Y, Fukai Y, Konno A, Hirai H.
Optimal different adeno-associated virus capsid/promoter combinations to target specific cell types in the common marmoset cerebral cortex.
Mol Ther Clin Dev. 2024, 32;4,101337; DOI: 10.1016/j.omtm.2024.101337
Konno A, Shinohara Y, Hirai H.
Production of Spinocerebellar Ataxia Type 3 Model Mice by Intravenous Injection of AAV-PHP.B Vectors.
Int J Mol Sci. 2024, 25(13), 7205; https://doi.org/10.3390/ijms25137205
Kinoshita K, Motomura K, Ushida K, Hirata Y, Konno A, Hirai H, Kotani S, Hitora-Imamura N, Kurauchi Y, Seki T, Katsuki H.
Nurr1 overexpression in the primary motor cortex alleviates motor dysfunction induced by intracerebral hemorrhage in the striatum in mice
Neurotherapeutics. 2024 May 3:e00370. doi: 10.1016/j.neurot.2024.e00370. Online ahead of print.
Watanave M, Kawachi M, Konno A, Aoki R, Fukai Y, Matsuzaki Y, Kaneko R, Hirai H.
Protein kinase Cγ negatively regulates the intrinsic excitability in zebrin-negative cerebellar Purkinje cells
Front Cell Neurosci. 2024 Feb 16;18:1349878. doi: 10.3389/fncel.2024.1349878. eCollection 2024.
Tan W, Ikoma Y, Takahashi Y, Konno A, Hirai H, Hirase H, Matsui K.
Anxiety control by astrocytes in the lateral habenula.
Neurosci Res. 2024 Feb 2:S0168-0102(24)00010-5. doi: 10.1016/j.neures.2024.01.006. Online ahead of print.
Kawabata H, Konno A, Matsuzaki Y, Sato Y, Kawachi M, Aoki R, Tsutsumi S, Togai S, Kobayashi R, Horii T, Hatada I, Hirai H.
Improving cell-specific recombination using AAV vectors in the murine CNS by capsid and expression cassette optimization.
Mol Ther Methods Clin Dev. 2024 Jan 10. in press doi: 10.1016/j.omtm.2024.101185
2023
論文 Articles
Morishima M, Matsumura S, Tohyama S, Nagashima T, Konno A, Hirai H, Watabe AM.
Excitatory subtypes of the lateral amygdala neurons are differentially involved in regulation of synaptic plasticity and excitation/inhibition balance in aversive learning in mice.
Front Cell Neurosci. 2023 Dec 14;17:1292822. doi: 10.3389/fncel.2023.1292822. eCollection 2023.
Nagashima T, Mikami K, Tohyama S, Konno A, Hirai H, Watabe AM.
State-dependent modulation of positive and negative affective valences by a parabrachial nucleus-to-ventral tegmental area pathway in mice.
Front Neural Circuits. 2023 Nov 29;17:1273322. doi: 10.3389/fncir.2023.1273322. eCollection 2023.
Ozawa K, Nagao M, Konno A, Iwai Y, Vittani M, Kusk P, Mishima T, Hirai H, Nedergaard M, Hirase H.
Astrocytic GPCR-Induced Ca2+ Signaling Is Not Causally Related to Local Cerebral Blood Flow Changes.
Int J Mol Sci. 2023 Sep 2;24(17):13590. doi: 10.3390/ijms241713590.
Murase S, Sakitani N, Maekawa T, Yoshino D, Takano K, Konno A, Hirai H, Saito T, Tanaka S, Shinohara K, Kishi T, Yoshikawa Y, Sakai T, Ayaori M, Inanami H, Tomiyasu K, Takashima A, Ogata T, Tsuchimochi H, Sato S, Saito S, Yoshino K, Matsuura Y, Funamoto K, Ochi H, Shinohara M, Nagao M, Sawada Y.
Interstitial-fluid shear stresses induced by vertically oscillating head motion lower blood pressure in hypertensive rats and humans.
Nat Biomed Eng. 2023 Nov;7(11):1350-1373. doi: 10.1038/s41551-023-01061-x. Epub 2023 Jul 6.
Ichinose S, Susuki Y, Hosoi N, Kaneko R, Ebihara M, Hirai H, Iwasaki H.
Interaction between Teneurin-2 and microtubules via EB proteins provides a platform for GABAA receptor exocytosis.
Elife. 2023 Jun 5;12:e83276. doi: 10.7554/eLife.83276.
Yaguchi K, Hagihara M, Konno A, Hirai H, Yukinaga H, Miyamichi K.
Dynamic modulation of pulsatile activities of oxytocin neurons in lactating wild-type mice.
PLoS One. 2023 May 10;18(5):e0285589. doi: 10.1371/journal.pone.0285589. eCollection 2023.
Kawabata H, Konno A, Matsuzaki Y, Hirai H.
A blood-brain barrier-penetrating AAV2 mutant created by a brain microvasculature endothelial cell-targeted AAV2 variant.
Mol Ther Methods Clin Dev. 2023 Mar 2;29:81-92. doi: 10.1016/j.omtm.2023.02.016. eCollection 2023 Jun 8.
Uggerud IM, Kråkenes T, Hirai H, Vedeler CA, Schubert M.
Development and Optimization of a Multilayer Rat Purkinje Neuron Culture.
Cerebellum. 2023 Jan 10. doi: 10.1007/s12311-022-01510-4. Online ahead of print.
2022
論文 Articles
Jin M, Matsumoto S, Ayaki T, Yamakado H, Taguchi T, Togawa N, Konno A, Hirai H, Nakajima H, Komai S, Ishida R, Chiba S, Takahashi R, Takao T, Hirotsune S.
DOPAnization of tyrosine in α-synuclein by tyrosine hydroxylase leads to the formation of oligomers.
Nat Commun. 2022 Nov 12;13(1):6880. doi: 10.1038/s41467-022-34555-4.
Okada Y, Hosoi N, Matsuzaki Y, Fukai Y, Hiraga A, Nakai J, Nitta K, Shinohara Y, Konno A, Hirai H.
Development of microglia-targeting adeno-associated viral vectors as tools to study microglial behavior in vivo.
Commun Biol. 2022 Nov 11;5(1):1224. doi: 10.1038/s42003-022-04200-3.
Ninomiya A, Amano I, Kokubo M, Takatsuru Y, Ishii S, Hirai H, Hosoi N, Koibuchi N.
Long-term depression-inductive stimulation causes long-term potentiation in mouse Purkinje cells with a mutant thyroid hormone receptor.
Proc Natl Acad Sci USA. 2022 Nov 8;119(45):e2210645119. doi: 10.1073/pnas.2210645119. Epub 2022 Nov 2.
Morizawa YM, Matsumoto M, Nakashima Y, Endo N, Aida T, Ishikane H, Beppu K, Moritoh S, Inada H, Osumi N, Shigetomi E, Koizumi S, Yang G, Hirai H, Tanaka K, Tanaka KF, Ohno N, Fukazawa Y, Matsui K.
Synaptic pruning through glial synapse engulfment upon motor learning.
Nat Neurosci. 2022 Nov;25(11):1458-1469. doi: 10.1038/s41593-022-01184-5. Epub 2022 Nov 1.
Wang X, Delle C, Asiminas A, Akther S, Vittani M, Brøgger P, Kusk P, Vo CT, Radovanovic T, Konno A, Hirai H, Fukuda M, Weikop P, Goldman SA, Nedergaard M, Hirase H.
Liver-secreted fluorescent blood plasma markers enable chronic imaging of the microcirculation.
Cell Rep Methods. 2022 Sep 21;2(10):100302. doi: 10.1016/j.crmeth.2022.100302. eCollection 2022 Oct 24.
Shuvaev AN, Belozor OS, Mozhei OI, Shuvaev AN, Fritsler YV, Khilazheva ED, Mosyagina AI, Hirai H, Teschemacher AG, Kasparov S.
Indirect Negative Effect of Mutant Ataxin-1 on Short- and Long-Term Synaptic Plasticity in Mouse Models of Spinocerebellar Ataxia Type 1.
Cells. 2022 Jul 20;11(14):2247. doi:10.3390/cells11142247
Tokuyama T, Uosaki H, Sugiura A, Nishitai G, Takeda K, Nagashima S, Shiiba I, Ito N, Amo T, Mohri S, Nishimura A, Nishida M, Konno A, Hirai H, Ishido S, Yoshizawa T, Shindo T, Takada S, Kinugawa S, Inatome R, Yanagi S
Protective roles of MITOL against myocardial senescence and ischemic injury partly via Drp1 regulation.
iScience. 2022 Jun 11;25(7):104582. doi: 10.1016/j.isci.2022.104582.
Inada K, Hagihara M, Tsujimoto K, Abe T, Konno A, Hirai H, Kiyonari H, Miyamichi K.
Plasticity of neural connections underlying oxytocin-mediated parental behaviors of male mice.
Neuron. 2022 Jun 15;110(12):2009-2023.e5. doi: 10.1016/j.neuron.2022.03.033. Epub 2022 Apr 19.
Ueda E, Ohta T, Konno A, Hirai H, Kurauchi Y, Katsuki H, Seki T.
D-Cysteine Activates Chaperone-Mediated Autophagy in Cerebellar Purkinje Cells via the Generation of Hydrogen Sulfide and Nrf2 Activation.
Cells. 2022 Apr 5;11(7):1230. doi: 10.3390/cells11071230.
Hirai H, Fukai Y, Konno A, Hosoi N.
Electrophysiological and Imaging Analysis of GFP-Tagged Protein Kinase C γ Translocation in Cerebellar Purkinje Cells.
Cerebellum. 2022 Oct;21(5):776-783. doi: 10.1007/s12311-022-01384-6. Epub 2022 Feb 26.
Sakai A, Yasui T, Watanave M, Tatsumi R, Yamamoto Y, Takano W, Tani Y, Okamura I, Hirai H, Takeda S.
Development of novel potent ligands for GPR85, an orphan G protein-coupled receptor expressed in the brain.
Genes Cells. 2022 May;27(5):345-355. doi: 10.1111/gtc.12931. Epub 2022 Mar 1.
Watanave M, Takahashi N, Hosoi N, Konno A, Yamamoto H, Yasui H, Kawachi M, Horii T, Matsuzaki Y, Hatada I, Hirai H.
Protein kinase Cγ in cerebellar Purkinje cells regulates Ca 2+-activated large-conductance K + channels and motor coordination
Proc Natl Acad Sci U S A. 2022 Feb 15;119(7):e2113336119. doi: 10.1073/pnas.2113336119.
Suzuki A, Kosugi S, Murayama E, Sasakawa E, Ohkawa N, Konno A, Hirai H, Inokuchi K.
A cortical cell ensemble in the posterior parietal cortex controls past experience-dependent memory updating.
Nat Commun. 2022 Jan 11;13(1):41. doi: 10.1038/s41467-021-27763-x
Ninomiya A, Mshaty A, Haijima A, Yajima H, Kokubo M, Khairinisa MA, Ariyani W, Fujiwara Y, Ishii S, Hosoi N, Hirai H, Amano I, Koibuchi N.
The neurotoxic effect of lactational PFOS exposure on cerebellar functional development in male mice.
Food Chem Toxicol. 2022 Jan;159:112751. doi: 10.1016/j.fct.2021.112751. Epub 2021 Dec 3.
2021
論文 Articles
Cendelin J, Cvetanovic M, Gandelman M, Hirai H, Orr HT, Pulst SM, Strupp M, Tichanek F, Tuma J, Manto M.
Consensus Paper: Strengths and Weaknesses of Animal Models of Spinocerebellar Ataxias and Their Clinical Implications.
Cerebellum. 2021 Aug 10. doi: 10.1007/s12311-021-01311-1. Online ahead of print.
Kawakami R, Matsui M, Konno A, Kaneko R, Shrestha S, Shrestha S, Sunaga H, Hanaoka H, Goto S, Hosojima M, Kabasawa H, Obokata M, Koitabashi N, Matsui H, Sasaki T, Saito A, Yanagita M, Hirai H, Kurabayashi M, Iso T.
Urinary FABP1 is a biomarker for impaired proximal tubular protein reabsorption and is synergistically enhanced by concurrent liver injury.
J Pathol. 2021 Dec;255(4):362-373. doi: 10.1002/path.5775. Epub 2021 Sep 1.
Ohta T, Morikawa Y, Sato M, Konno A, Hirai H, Kurauchi Y, Hisatsune A, Katsuki H, Seki T.
Therapeutic potential of d-cysteine against in vitro and in vivo models of spinocerebellar ataxia.
Exp Neurol. 2021 Sep;343:113791. doi: 10.1016/j.expneurol.2021.113791. Epub 2021 Jun 19.
Radhiyanti PT, Konno A, Matsuzaki Y, Hirai H.
Comparative study of neuron-specific promoters in mouse brain transduced by intravenously administered AAV-PHP.eB.
Neurosci Lett. 2021 Jun 21;756:135956. doi: 10.1016/j.neulet.2021.135956. Epub 2021 May 11.
Nagao S, Hirai H, Kano M, Yuzaki M.
Masao Ito-A Visionary Neuroscientist with a Passion for the Cerebellum.
Neuroscience. 2021 May 10;462:1-3. doi: 10.1016/j.neuroscience.2021.02.028.
Shuvaev AN, Belozor OS, Mozhei O, Yakovleva DA, Potapenko IV, Shuvaev AN, Smolnikova MV, Salmin VV, Salmina AB, Hirai H, Teschemacher AG, Kasparov S.
Chronic optogenetic stimulation of Bergman glia leads to dysfunction of EAAT1 and Purkinje cell death, mimicking the events caused by expression of pathogenic ataxin-1.
Neurobiol Dis. 2021 Jul;154:105340. doi: 10.1016/j.nbd.2021.105340. Epub 2021 Mar 19.
Sugimoto H, Horii T, Hirota JN, Sano Y, Shinoda Y, Konno A, Hirai H, Ishizaki Y, Hirase H, Hatada I, Furuichi T, Sadakata T.
The Ser19Stop single nucleotide polymorphism (SNP) of human PHYHIPL affects the cerebellum in mice.
Mol Brain. 2021 Mar 12;14(1):52. doi: 10.1186/s13041-021-00766-x.
Hoshino C, Konno A, Hosoi N, Kaneko R, Mukai R, Nakai J, Hirai H.
GABAergic neuron-specific whole-brain transduction by AAV-PHP.B incorporated with a new GAD65 promoter.
Mol Brain. 2021 Feb 15;14(1):33. doi: 10.1186/s13041-021-00746-1.
Ohgami N, Iizuka A, Hirai H, Yajima I, Iida M, Shimada A, Tsuzuki T, Jijiwa M, Asai N, Takahashi M, Kato M.
Loss-of-function mutation of c-Ret causes cerebellar hypoplasia in mice with Hirschsprung disease and Down’s syndrome.
J Biol Chem. Jan-Jun 2021;296:100389. doi: 10.1016/j.jbc.2021.100389. Epub 2021 Feb 6.
2020
論文 Articles
Inoue A, Kobayashi T, Hirai H, Kanaya N, Kohara K.
Protocol for BATTLE-1EX: A High-Resolution Imaging Method to Visualize Whole Synaptic Structures and their Components in the Nervous System.
J STAR Protoc. 2020 Nov 25;1(3):100166. doi: 10.1016/j.xpro.2020.100166. eCollection 2020 Dec 18.
Konno A, Hirai H.
Efficient whole brain transduction by systemic infusion of minimally purified AAV-PHP.eB.
J Neurosci Methods. 2020 Dec 1;346:108914. doi: 10.1016/j.jneumeth.2020.108914. Epub 2020 Aug 15.
Sato M, Ohta T, Morikawa Y, Konno A, Hirai H, Kurauchi Y, Hisatsune A, Katsuki H, Seki T.
Ataxic phenotype and neurodegeneration are triggered by the impairment of chaperone-mediated autophagy in cerebellar neurons.
Neuropathol Appl Neurobiol. 2021 Feb;47(2):198-209. doi: 10.1111/nan.12649. Epub 2020 Aug 9.
Oe Y, Wang X, Patriarchi T, Konno A, Ozawa K, Yahagi K, Hirai H, Tsuboi T, Kitaguchi T, Tian L, McHugh TJ, Hirase H.
Author Correction: Distinct temporal integration of noradrenaline signaling by astrocytic second messengers during vigilance.
Nat Commun. 2020 Jul 7;11(1):3447. doi: 10.1038/s41467-020-17059-x.
Kohara K, Inoue A, Nakano Y, Hirai H, Kobayashi T, Maruyama M, Baba R, Kawashima C.
BATTLE: Genetically Engineered Strategies for Split-Tunable Allocation of Multiple Transgenes in the Nervous System.
iScience. 2020 Jun 26;23(6):101248. doi: 10.1016/j.isci.2020.101248. Epub 2020 Jun 7.
Sato M, Ueda E, Konno A, Hirai H, Kurauchi Y, Hisatsune A, Katsuki H, Seki T.
Glucocorticoids negatively regulates chaperone mediated autophagy and microautophagy.
Biochem Biophys Res Commun. 2020 Jul 12;528(1):199-205. doi: 10.1016/j.bbrc.2020.04.132. Epub 2020 May 30.
Yasui H, Matsuzaki Y, Konno A, Hirai H.
Global knockdown of retinoid-related orphan receptor α in mature Purkinje cells reveals aberrant cerebellar phenotypes of spinocerebellar ataxia.
Neuroscience. 2021 May 10;462:328-336. doi: 10.1016/j.neuroscience.2020.04.004. Epub 2020 Apr 8.
Chao OY, Marron Fernandez de Velasco E, Pathak SS, Maitra S, Zhang H, Duvick L, Wickman K, Orr HT, Hirai H, Yang YM.
Targeting Inhibitory Cerebellar Circuitry to Alleviate Behavioral Deficits in a Mouse Model for Studying Idiopathic Autism.
Neuropsychopharmacology. 2020 Jun;45(7):1159-1170. doi: 10.1038/s41386-020-0656-5.
Ryu Y, Maekawa T, Yoshino D, Sakitani N, Takashima A, Inoue T, Suzurikawa J, Toyohara J, Tago T, Makuuchi M, Fujita N, Sawada K, Murase S, Watanave M, Hirai H, Sakai T, Yoshikawa Y, Ogata T, Shinohara M, Nagao M, Sawada Y.
Mechanical Regulation Underlies Effects of Exercise on Serotonin-Induced Signaling in the Prefrontal Cortex Neurons.
iScience. 2020 Feb 21;23(2):100874. doi: 10.1016/j.isci.2020.100874. Epub 2020 Jan 31.
Oe Y, Wang X, Patriarchi T, Konno A, Ozawa K, Yahagi K, Hirai H, Tian L, McHugh TJ, Hirase H.
Distinct temporal integration of noradrenaline signaling by astrocytic second messengers during vigilance.
Nat Commun. 2020 Jan 24;11(1):471. doi: 10.1038/s41467-020-14378-x.
2019
論文 Articles
Matsumoto K, Mitani TT, Horiguchi SA, Kaneshiro J, Murakami TC, Mano T, Fujishima H, Konno A, Watanabe TM, Hirai H, Ueda HR.
Advanced CUBIC tissue clearing for whole-organ cell profiling.
Nat Protoc. 2019 Dec;14(12):3506-3537. Epub 2019 Nov 20.
Hosoi N, Shibasaki K, Hosono M, Konno A, Shinoda Y, Kiyonari H, Inoue K, Muramatsu SI, Ishizaki Y, Hirai H, Furuichi T, Sadakata T
Deletion of class II ARFs in mice causes tremor by the Nav1.6 loss in cerebellar Purkinje cell axon initial segments.
J Neurosci. 2019 Jun 14. pii: 2002-18. [Epub ahead of print]
Sato M, Seki T, Konno A, Hirai H, Kurauchi Y, Hisatsune A, Katsuki H
Rapamycin activates mammalian microautophagy.
J Pharmacol Sci. 2019 May 24. pii: S1347-8613(19)34062-9. [Epub ahead of print]
Matsuzaki Y, Tanaka M, Hakoda S, Masuda T, Miyata R, Konno A, Hirai H
Neurotropic Properties of AAV-PHP.B Are Shared among Diverse Inbred Strains of Mice
Mol Ther. 2019 Apr 10;27(4):700-704. Epub 2019 Feb 28.
Cendelin J, Buffo A, Hirai H, Magrassi L, Mitoma H, Sherrard R, Vozeh F, Manto M
Task Force Paper On Cerebellar Transplantation: Are We Ready to Treat Cerebellar Disorders with Cell Therapy?
Cerebellum. 2019 Jan 3. [Epub ahead of print]
Watanave M, Hoshino C, Konno A, Fukuzaki Y, Matsuzaki Y, Ishitani T, Hirai H
Pharmacological enhancement of retinoid-related orphan receptor α function mitigates spinocerebellar ataxia type 3 pathology.
Neurobiol Dis. 2019 Jan;121:263-273. Epub 2018 Oct 19.
平井宏和
ウイルスベクター経静脈投与による脊髄小脳変性症動物モデルの作出
Clinical Neuroscience. 2019 Vol.37 (19年) 08月号: 998-1002
今野歩, 平井宏和
ウイルスベクターの静脈投与によるマウス脳全域への遺伝子導入
実験医学. 2019; 37(4): 581-587
2018
論文 Articles
Watanave M, Matsuzaki Y, Nakajima Y, Ozawa A, Yamada M, Hirai H
Contribution of Thyrotropin-Releasing Hormone to Cerebellar Long-Term Depression and Motor Learning.
Front Cell Neurosci. 2018 Dec 12.
Seki T, Sato M, Konno A, Hirai H, Kurauchi Y, Hisatsune A, Katsuki H.
d-Cysteine promotes dendritic development in primary cultured cerebellar Purkinje cells via hydrogen sulfide production.
Mol Cell Neurosci. 2018 Dec;93:36-47. Epub 2018 Oct 19.
Shinohara Y, Konno A, Nitta K, Matsuzaki Y, Yasui H, Suwa J, Hiromura K, Hirai H.
Effects of Neutralizing Antibody Production on AAV-PHP.B-Mediated Transduction of the Mouse Central Nervous System.
Mol Neurobiol. 2019 Jun;56(6):4203-4214. Epub 2018 Oct 5.
Seki T, Sato M, Kibe Y, Ohta T, Oshima M, Konno A, Hirai H, Kurauchi Y, Hisatsune A, Katsuki H.
Lysosomal dysfunction and early glial activation are involved in the pathogenesis of spinocerebellar ataxia type 21 caused by mutant transmembrane protein 240.
Neurobiol Dis. 2018 Sep 2. pii: S0969-9961(18)30519-9.
Gaffield MA, Rowan MJM, Amat SB, Hirai H, Christie JM.
Inhibition gates supralinear Ca2+ signaling in Purkinje cell dendrites during practiced movements.
Elife. 2018 Aug 17;7. pii: e36246.
Hirai H and Kano M.
Type 1 metabotropic glutamate receptor and its signaling molecules as therapeutic targets for the treatment of cerebellar disorders.
Curr Opin Pharmacol. 2018 Feb;38:51-58.
Hirai H.
Protein Kinase C in the Cerebellum: Its Significance and Remaining Conundrums.
Cerebellum. 2018 Feb;17(1):23-27.
Ogawa Y, Kakumoto K, Yoshida T, Kuwako KI, Miyazaki T, Yamaguchi J, Konno A, Hata J, Uchiyama Y, Hirai H, Watanabe M, Darnell RB, Okano H, Okano HJ
Elavl3 is essential for the maintenance of Purkinje neuron axons.
Sci Rep. 2018 Feb 9;8(1):2722.
Matsuzaki Y, Konno A, Mochizuki R, Shinohara Y, Nitta K, Okada Y, Hirai H
Intravenous administration of the adeno-associated virus-PHP.B capsid fails to upregulate transduction efficiency in the marmoset brain.
Neurosci Lett. 2018 Feb 5;665:182-188. Epub 2017 Nov 24.
平井宏和
トピック：遺伝子導入
脳科学辞典. 2018. doi:10.14931/bsd.7623
平井宏和
トピック：ウイルスベクター
脳科学辞典. 2018. doi:10.14931/bsd.7632
2017
論文 Articles
Takahashi N, Shuvaev AN, Konno A, Matsuzaki Y, Watanave M, Hirai H.
Regulatory connection between the expression level of classical protein kinase C and pruning of climbing fibers from cerebellar Purkinje cells.
J Neurochem. 2017 Dec;143(6):660-670. Epub 2017 Nov 29.
Nitta K, Matsuzaki Y, Konno A, Hirai H
Minimal Purkinje Cell-Specific PCP2/L7 Promoter Virally Available for Rodents and Non-human Primates.
Mol Ther Methods Clin Dev. 2017 Jul 27;6:159-170.
Harada K, Ito M, Wang X, Tanaka M, Wongso D, Konno A, Hirai H, Hirase H, Tsuboi T, Kitaguchi T.
Red fluorescent protein-based cAMP indicator applicable to optogenetics and in vivo imaging.
Scientific Reports. 2017 Aug 4;7(1):7351
Hattori T, Kaji M, Ishii H, Jureepon R, Takarada-Iemata M, Minh Ta H, Manh Le T, Konno A, Hirai H, Shiraishi Y, Ozaki N, Yamamoto Y, Okamoto H, Yokoyama S, Higashida H, Kitao Y, Hori O.
CD38 positively regulates postnatal development of astrocytes cell-autonomously and oligodendrocytes non-cell-autonomously.
Glia. 2017 Jun;65(6):974-989. Epub 2017 Mar 13.
Shinohara Y, Ohtani T, Konno A, Hirai H
Viral Vector-Based Evaluation of Regulatory Regions in the Neuron-Specific Enolase (NSE) Promoter in Mouse Cerebellum In Vivo.
Cerebellum. 2017 Dec;16(5-6):913-922.
Matsuzaki Y, Konno A, Mukai R, Honda F, Hirato M, Yoshimoto Y, Hirai H.
Transduction Profile of the Marmoset Central Nervous System Using Adeno-Associated Virus Serotype 9 Vectors.
Molecular Neurobiology. 2017 Apr;54(3):1745-1758. Epub 2016 Feb 16.
Gonçalves N, Simões AT, Prediger RD, Hirai H, Cunha RA, Pereira de Almeida L
Caffeine alleviates progressive motor deficits in a transgenic mouse model of spinocerebellar ataxia.
Ann Neurol. 2017 Mar;81(3):407-418. Epub 2017 Feb 17.
Shuvaev AN, Hosoi N, Sato Y, Yanagihara D, Hirai H
Progressive impairment of cerebellar mGluR signalling and its therapeutic potential for cerebellar ataxia in spinocerebellar ataxia type 1 model mice.
Journal of Physiology. 2017 Jan 1;595(1):141-164. Epub 2016 Sep 15.
平井宏和
バクロフェンで脊髄小脳失調症１型の運動失調がよくなるのか？
全国脊髄小脳変性症（SCD）・多系統萎縮症（MSA）友の会ニュース. No. 226: 10-14. 2017.04.25発行
平井宏和
ニューロン特異的エノラーゼ（NSE）”は炎症があるとニューロンではなくグリア細胞で産生される
生化学. 2017; 89(2): 241-243. doi:10.14952/SEIKAGAKU.2017.890241
平井宏和
小脳の機能（基底核と小脳−その相違と連関）
Clinical Neuroscience. 35巻01月号: 28-32. 2017.01.01発行
2016
論文 Articles
Arsenault J, Gholizadeh S, Niibori Y, Pacey LK, Halder SK, Koxhioni E, Konno A, Hirai H, Hampson DR.
FMRP Expression Levels in Mouse CNS Neurons Determine Behavioral Phenotype.
Human Gene Therapy. 2016 Dec;27(12):982-996. Epub 2016 Sep 7.
Ito E, Tomaru Y, Iizuka A, Hirai H, Kato T.
Adaptive Local Thresholding for Co-Localization Detection in Multi-Channel Fluorescence Microscopic Images.
IEICE Transactions on Information and Systems. 2016 Nov 1;99(11):2851-2855.
Huda F, Fan Y, Suzuki M, Konno A, Matsuzaki Y, Takahashi N, Chan JK, Hirai H.
Fusion of Human Fetal Mesenchymal Stem Cells with “Degenerating” Cerebellar Neurons in Spinocerebellar Ataxia Type 1 Model Mice.
PLoS One. 2016 Nov 1;11(11):e0164202.
Shinohara Y, Konno A, Takahashi N, Matsuzaki Y, Kishi S, Hirai H.
Viral Vector-Based Dissection of Marmoset GFAP Promoter in Mouse and Marmoset Brains.
PLoS One. 2016 Aug 29;11(8):e0162023.
Takahashi H, Ogawa Y, Yoshihara S, Asahina R, Kinoshita M, Kitano T, Kitsuki M, Tatsumi K, Okuda M, Tatsumi K, Wanaka A, Hirai H, Stern PL, Tsuboi A.
A Subtype of Olfactory Bulb Interneurons Is Required for Odor Detection and Discrimination Behaviors.
Journal of Neuroscience. 2016 Aug 3;36(31):8210-27.
Sato M, Seki T, Konno A, Hirai H, Kurauchi Y, Hisatsune A, Katsuki H.
Fluorescent-based evaluation of chaperone-mediated autophagy and microautophagy activities in cultured cells.
Genes Cells. 2016 Aug;21(8):861-73. Epub 2016 Jul 5.
Sawada Y, Konno A, Nagaoka J, Hirai H.
Inflammation-induced reversible switch of the neuron-specific enolase promoter from Purkinje neurons to Bergmann glia.
Scientific Reports. 2016 Jun 13;6:27758.
Yanai T, Kurosawa A, Nikaido Y, Nakajima N, Saito T, Osada H, Konno A, Hirai H, Takeda S.
Identification and molecular docking studies for novel inverse agonists of SREB, super conserved receptor expressed in brain.
Genes Cells. 2016 Jul;21(7):717-27. Epub 2016 May 17.
Suto N, Mieda T, Iizuka A, Nakamura K, Hirai H.
Morphological and Functional Attenuation of Degeneration of Peripheral Neurons by Mesenchymal Stem Cell-Conditioned Medium in Spinocerebellar Ataxia Type 1-Knock-in Mice.
CNS Neuroscience & Therapeutics. 2016 Aug;22(8):670-6. Epub 2016 May 3.
Monai H, Ohkura M, Tanaka M, Oe Y, Konno A, Hirai H, Mikoshiba K, Itohara S, Nakai J, Iwai Y, Hirase H.
Calcium imaging reveals glial involvement in transcranial direct current stimulation-induced plasticity in mouse brain.
Nature Communications. 2016 Mar 22;7:11100.
Conceição M, Mendonça L, Nóbrega C, Gomes C, Costa P, Hirai H, Moreira JN, Lima MC, Manjunath N, Pereira de Almeida L.
Intravenous administration of brain-targeted stable nucleic acid lipid particles alleviates Machado-Joseph disease neurological phenotype.
Biomaterials. Volume 82, March 2016, Pages 124–137
Conceição M, Mendonça L, Nóbrega C, Gomes C, Costa P, Hirai H, Moreira JN, Lima MC, Manjunath N, Pereira de Almeida L.
Safety profile of the intravenous administration of brain-targeted stable nucleic acid lipid particles.
Data Brief. 2016 Jan 20;6:700-5.
2015
論文 Articles
Mieda T, Suto N, Iizuka A, Matsuura S, Iizuka H, Takagishi K, Nakamura K, Hirai H.
Mesenchymal stem cells attenuate peripheral neuronal degeneration in spinocerebellar ataxia type 1 knockin mice.
J Neurosci Res. 2016 Mar;94(3):246-52. Epub 2015 Dec 28.
Ageta-Ishihara N, Yamazaki M, Konno K, Nakayama H, Abe M, Hashimoto K, Nishioka T, Kaibuchi K, Hattori S, Miyakawa T, Tanaka K, Huda F, Hirai H, Hashimoto K, Watanabe M, Sakimura K, Kinoshita M.
A CDC42EP4/septin-based perisynaptic glial scaffold facilitates glutamate clearance.
Nat Commun. 2015 Dec 10;6:10090.
Nóbrega C, Carmo-Silva S, Albuquerque D, Vasconcelos-Ferreira A, Vijayakumar UG, Mendonça L, Hirai H, Pereira de Almeida L.
Re-establishing ataxin-2 downregulates translation of mutant ataxin-3 and alleviates Machado-Joseph disease.
Brain 2015 Dec;138(Pt 12):3537-54.
Duarte-Neves J, Gonçalves N, Cunha-Santos J, Simões AT, den Dunnen WF, Hirai H, Kügler S, Cavadas C, Pereira de Almeida L.
Neuropeptide Y mitigates neuropathology and motor deficits in mouse models of Machado-Joseph disease.
Hum Mol Genet 2015 Oct 1;24(19):5451-63.
Iizuka A, Matsuzaki Y, Konno A, Hirai H.
Plasticity of the developmentally arrested staggerer cerebellum in response to exogenous RORα.
Brain Structure and Function 2016 Jul;221(6):2879-89. Epub 2015 Jun 30.
Kusakari S, Saitow F, Ago Y, Shibasaki K, Sato-Hashimoto M, Matsuzaki Y, Kotani T, Murata Y, Hirai H, Matsuda T, Suzuki H, Matozaki T, Ohnishi H.
Shp2 in forebrain neurons regulates synaptic plasticity, locomotion, and memory formation in mice.
Molecular and Cellular Biology 2015 May 1;35(9):1557-72.
Iizuka A, Nakamura K, Hirai H.
Long-term oral administration of the NMDA receptor antagonist memantine extends life span in spinocerebellar ataxia type 1 knock-in mice.
Neurosci Lett 2015 Apr 10;592:37-41.
Nakamura K, Mieda T, Suto N, Matsuura S, Hirai H.
Mesenchymal Stem Cells as a Potential Therapeutic Tool for Spinocerebellar Ataxia.
Cerebellum 2015 Apr;14(2):165-70.
Mendonça LS, Nóbrega C, Hirai H, Kaspar BK, Pereira de Almeida L
Transplantation of cerebellar neural stem cells improves motor coordination and neuropathology in Machado-Joseph disease mice.
Brain 2015 Feb;138(Pt 2):320-35.
Uesaka N, Uchigashima M, Mikuni T, Hirai H, Watanabe M, Kano M.
Retrograde Signaling for Climbing Fiber Synapse Elimination.
Cerebellum 2015 Feb;14(1):4-7.
Takahashi H, Adachi N, Shirafuji T, Danno S, Ueyama T, Vendruscolo M, Shuvaev AN, Sugimoto T, Seki T, Hamada D, Irie K, Hirai H, Sakai N, Saito N.
Identification and characterization of PKCγ, a kinase associated with SCA14, as an amyloidogenic protein.
Human Molecular Genetics 2015 Jan 15;24(2):525-39.
平井宏和
脊髄小脳変性症・多系統萎縮症に対する幹細胞研究の現状
脊髄小脳変性症・多系統萎縮症 Q&A 172 平成27年3月発行
2014
論文 Articles
Irie T, Matsuzaki Y, Sekino Y, Hirai H.
Kv3.3 channels harboring a mutation of spinocerebellar ataxia type 13 alterexcitability and induce cell death in cultured cerebellar Purkinje cells.
The Journal of Physiology 2014 Jan 1;592(Pt 1):229-47.
Konno A, Shuvaev AN, Miyake N, Miyake K, Iizuka A, Matsuura S, Huda F, Nakamura K, Yanagi S, Shimada T, Hirai H.
Mutant Ataxin-3 with an Abnormally Expanded Polyglutamine Chain Disrupts Dendritic Development and Metabotropic Glutamate Receptor Signaling in Mouse Cerebellar Purkinje Cells.
The Cerebellum 2014 Feb;13(1):29-41.
Matsuzaki Y, Oue M, Hirai H.
Generation of a neurodegenerative disease mouse model using lentiviral vectors carrying an enhanced synapsin I promoter.
The Journal of Neuroscience Methods 2014 Feb 15;223:133-43.
Matsuura S, Shuvaev AN, Iizuka A, Nakamura K, Hirai H.
Mesenchymal Stem Cells Ameliorate Cerebellar Pathology in a Mouse Model of Spinocerebellar Ataxia Type 1.
The Cerebellum 2014 Jun;13(3):323-30.
Okonogi N, Nakamura K, Suzuki Y. Suto N. Suzue K. Kaminama T. Nakano T. Hirai H.
Cranial irradiation induces bone marrow-derived microglia in adult mouse brain tissue.
Journal of Radiation Research 2014 Jul;55(4):713-9.
Uesaka N, Uchigashima M, Mikuni T, Nakazawa T, Nakao H, Hirai H, Aiba A, Watanabe M, Kano M.
Retrograde semaphorin signaling regulates synapse elimination in the developing mouse brain.
Science 2014 May 30;344(6187):1020-3.
Huda F, Konno A. Matsuzaki Y. Goenawan H. Miyake K. Shimada T and Hirai H.
Distinct transduction profiles in the CNS via three injection routes of AAV9 and the application to generation of a neurodegenerative mouse model.
Molecular Therapy-Methods & Clinical Development 2014 Aug 6.
Saida H, Matsuzaki Y, Takayama K, Iizuka A, Konno A, Yanagi S, Hirai H.
One-year follow-up of transgene expression by integrase-defective lentiviral vectors and their therapeutic potential in spinocerebellar ataxia model mice.
Gene Therapy 2014 Sep;21(9):820-7.
Yoshihara S, Takahashi H, Nishimura N, Kinoshita M, Asahina R, Kitsuki M. Tatsumi K, Furukawa-Hibi Y, Hirai H, Nagai T, Yamada K, Tsuboi A.
Npas4 regulates Mdm2 and thus Dcx in experience-dependent dendritic spine development of newborn olfactory bulb interneurons.
Cell Reports 2014 Aug 7;8(3):843-57.
2013
論文 Articles
Nóbrega C, Nascimento-Ferreira I, Onofre I, Albuquerque D, Hirai H,Déglon N, de Almeida LP.
Silencing mutant ataxin-3 rescues motor deficits and neuropathology in Machado-Joseph disease transgenic mice.
PLoS One 2013;8(1):e52396.
Takechi Y, Mieda T, Iizuka A, Toya S, Suto N, Takagishi K, Nakazato Y, Nakamura K, Hirai H.
Impairment of spinal motor neurons in spinocerebellar ataxia type 1-knock-in mice.
Neuroscience Letters 2013 Feb 22;535:67-72.
Liu HX, Lopatina O, Higashida C, Fujimoto H, Akther S, Inzhutova A, Liang M, Zhong J, Tsuji T, Yoshihara T, Sumi K, Ishiyama M, Ma WJ, Ozaki M, Yagitani S, Yokoyama S, Mukaida N, Sakurai T, Hori O, Yoshioka K, Hirao A, Kato Y, Ishihara K, Kato I, Okamoto H, Cherepanov SM, Salmina AB, Hirai H, Asano M, Brown DA, Nagano I, Higashida H
Displays of paternal mouse pup retrieval following communicative interaction with maternal mates.
Nature Communications 2013;4:1346.
Yamaura H. Hirai H, Yanagihara D.
Postural dysfunction in a transgenic mouse model of spinocerebellar ataxia type 3.
Neuroscience 2013 Jul 23;243:126-35.
Mikuni T, Uesaka N, Okuno H, Hirai H, Deisseroth K, Bito H, Kano M.
Arc/Arg3.1 is a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum.
Neuron 2013 Jun 19;78(6):1024-35.
Nascimento-Ferreira I, Nóbrega C, Vasconcelos-Ferreira A, Onofre I, Albuquerque D, Aveleira C, Hirai H, Déglon N, Pereira de Almeida L.
Beclin 1 mitigates motor and neuropathological deficits in genetic mouse models of Machado-Joseph disease.
Brain 2013 Jul;136(Pt 7):2173-88.
Akther S, Korshnova N, Zhong J, Liang M, Cherepanov SM, Lopatina O, Komleva YK, Salmina AB, Nishimura T, Fakhrul AA, Hirai H, Kato I, Yamamoto Y, Takasawa S, Okamoto H, Higashida H.
CD38 in the nucleus accumbens and oxytocin are related to paternal behavior in mice.
Molecular Brain 2013 Sep 23;6(1):41.
Miki T, Hirai H, Takahashi T.
Activity-dependent neurotrophin signaling underlies developmental switch of Ca2+ channel subtypes mediating neurotransmitter release.
The Journal of Neuroscience 2013 Nov 27;33(48):18755-63.
総説 Review
平井宏和
「第5章 小脳への遺伝子導入」
小脳と運動失調 小脳はなにをしているのか（アクチュアル 脳・神経疾患の臨床）
（ISBN: 978-4-521-73442-2) 辻省次(編集), 西澤正豊(編集) 中山書店
学会発表 Conference Presentation
Hirokazu Hirai
Progress of spinocerebellar ataxia research on pathology, model animals and gene/stem cell therapies: Toward clinical application
第19回日本遺伝子治療学会学術集会・シンポジウム(S2-2) 2013年7月5日
Hirokazu Hirai
Virus-mediated highly efficient and cell-type specific gene expression in the cerebellum – Modulation of cathepsin K activity and development of unique promoters –
第90回日本生理学会大会・シンポジウム(1S13E-1) 2013年3月27日
2012
論文 Articles
Jin D, Muramatsu SI, Shimizu N, Yokoyama S, Hirai H, Yamada K, Liu HX, Higashida C, Hashii M, Higashida A, Asano M, Ohkuma S, Higashida H.
Dopamine release via the vacuolar ATPase V0 sector c-subunit, confirmed in N18 neuroblastoma cells, results in behavioral recovery in hemiparkinsonian mice.
Neurochemistry International 2012 Nov;61(6):907-12
Yoshihara SI, Takahashi H, Nishimura N, Naritsuka H, Shirao T, Hirai H, Yoshihara Y, Mori K, Stern PL, Tsuboi A.
5T4 Glycoprotein Regulates the SensoryInput-Dependent Development of a Specific Subtype of Newborn Interneurons inthe Mouse Olfactory Bulb.
Journal of Neuroscience 2012 Feb 8;32(6):2217-2226.
Hirai H.
Basic research on cerebellar gene therapy using lentiviral vectors.
The Cerebellum 2012 Jun 11(2): 443-5
Uesaka N. Mikuni T. Hashimoto K. Hirai H. Sakimura K. Kano M.
Organotypic Coculture Preparation for the Study of Developmental SynapseElimination in Mammalian Brain.
Journal of Neuroscience 2012 Aug 22; 32(34): 11657-11670
Goenawan H. Hirai H.
Modulation of lentiviral vector tropism in cerebellar Purkinje cells in vivo by a lysosomal cysteine protease cathepsin K.
Journal of NeuroVirology 2012 Dec;18(6):521-31
Oue M, Handa H, Matsuzaki Y, Suzue K, Murakami H, Hirai H.
The murine stem cell virus promoter drives correlated transgene expression in the leukocytes and cerebellar Purkinje cells of transgenic mice.
PLoS One 2012;7(11):e51015.
総説 Review
平井宏和
News & Hot Paper Digest
「神経変性疾患でなぜ神経細胞が死ぬのか？」
羊土社・実験医学 Vol.30 No.1, 64-65, 2012 Jan
2011
論文 Articles
Mitsumura K, Hosoi N, Furuya N, Hirai H.
Disruption of metabotropic glutamate receptor signalling is a major defect at cerebellar parallel fibre-Purkinje cell synapses in staggerer mutant mice.
The Journal of Physiology 2011 May 9; 589:3191-3209. Epub 2011 Jul 1
Shuvaev AN, Horiuchi H, Seki T, Goenawan H, Irie T, Iizuka A, Sakai N, Hirai H.
Mutant PKC{gamma} in spinocerebellar ataxia type 14 disrupts synapse elimination and long-term depression in Purkinje cells in vivo.
The Journal of Neuroscience 2011 Oct 5;31(40):14324-34.
Hirai H.
Basic research on cerebellar gene therapy using lentiviral vectors.
The Cerebellum 2011 Nov 26. [Epub ahead of print]
総説 Review
Hirai H, Iizuka A.
Chapter 22. Recent developments in gene therapy research targeted to cerebellar disorders.
Gene Therapy Applications (ISBN:978-953-307-541-9). Edited by Chunsheng Kang, Publisher: InTech, Aug 2011.
平井宏和
News & Hot Paper Digest
「多発性硬化症の最初の病変は脱髄ではなく軸索変性である」
羊土社・実験医学 Vol.29 No.13, 2130, 2011 Aug
平井宏和
News & Hot Paper Digest
「脳のマクロファージ、ミクログリアはどこからやってくるのか？」
羊土社・実験医学 Vol.29 No.6, 904-905, 2011 Apr
2010
論文 Articles
Sasaki J, Kofuji S, Itoh R, Momiyama T, Takayama K, Murakami H, Chida S, Tsuya Y, Takasuga S, Eguchi S, Asanuma K, Horie Y, Miura K, Davies EM, Mitchell C, Yamazaki M, Hirai H, Takenawa T, Suzuki A, Sasaki T.
The PtdIns(3,4)P(2) phosphatase INPP4A is a suppressor of excitotoxic neuronal death.
Nature 2010 May 27;465(7297):497-501. Epub 2010 May 12.
Munesue T, Yokoyama S, Nakamura K, Anitha A, Yamada K, Hayashi K, Asaka T, Liu HX, Jin D, Koizumi K, Islam MS, Huang JJ, Ma WJ, Kim UH, Kim SJ, Park K, Kim D, Kikuchi M, Ono Y, Nakatani H, Suda S, Miyachi T, Hirai H, Salmina A, Pichugina YA, Soumarokov AA, Takei N, Mori N, Tsujii M, Sugiyama T, Yagi K, Yamagishi M, Sasaki T, Yamasue H, Kato N, Hashimoto R, Taniike M, Hayashi Y, Hamada J, Suzuki S, Ooi A, Noda M, Kamiyama Y, Kido MA, Lopatina O, Hashii M, Amina S, Malavasi F, Huang EJ, Zhang J, Shimizu N, Yoshikawa T, Matsushima A, Minabe Y, Higashida H.
Two genetic variants of CD38 in subjects with autism spectrum disorder and controls.
Neuroscience Research 2010 Jun;67(2):181-91. Epub 2010 May 1
Sawada Y, Kajiwara G, Iizuka A, Takayama K, Shuvaev AN, Koyama C, Hira H.
High Transgene Expression by Lentiviral Vectors Causes Maldevelopment of Purkinje Cells in Vivo.
The Cerebellum 2010 Sep;9(3):291-302.
総説 Review
平井宏和
News & Hot Paper Digest
「細胞膜に係留された神経ペプチド毒素によるシナプス伝達の遮断」
羊土社・実験医学 Vol.28 No.9, 1401-1402, 2010 June
2009
論文 Articles
Iizuka A, Takayama K, Torashima T, Yamasaki M, Koyama C, Mitsumura K, Watanabe M, Hirai H.
Lentiviral vector-mediated rescue of motor behavior in spontaneously occurring hereditary ataxic mice.
Neurobiology of Disease 2009 Sep;35(3):457-65. Epub 2009 Jun 30.
Torashima T, Iizuka A, Horiuchi H, Mitsumura K, Yamasaki M, Koyama C, Takayama K, IinoM, Watanabe M, Hirai H.
Rescue of abnormal phenotypes in delta2 glutamate receptor-deficient mice the extracellular N-terminal and intracellular C-terminal domains of the delta2 glutamate receptor.
European Journal of Neuroscience 2009 Aug;30(3):355-65. Epub 2009 Jul 15
Oue M, Mitsumura K, Torashima T, Koyama C, Yamaguchi H, Furuya N, Hirai H.
Characterization of mutant mice that express polyglutamine in cerebellar Purkinje cells.
Brain Research 2009 Feb 19;1255:9-17.
Shiba K, Torashima T, Hirai H, Ogawa K, Akhter N, Nakajima K, Kinuya S, Mori H.
Potential usefulness of D(2)R reporter gene imaging by IBF as gene therapy monitoring for cerebellar neurodegenerative diseases.
Journal of Cerebral Blood Flow & Metabolism 2009 Feb;29(2):434-40.
Kobayashi T, Hirai H, Iino M, Fuse I, Mitsumura K, Washiyama K, Kasai S, Ikeda K.
Inhibitory effects of the antiepileptic drug ethosuximide on G protein-activated inwardly rectifying K+ channels.
Neuropharmacology 2009 Feb;56(2):499-506.
総説 Review
平井 宏和
【特集 遺伝子－脳回路－行動】
脳の遺伝子治療の可能性と展望
生体の科学. Vol.60 No.1, 23-30, 2009
平井宏和
News&Hot Paper Digest
「マイクロRNAが脊髄小脳変性症１型の病態に関与」
羊土社・実験医学. Vol.3, 104-405, 2009
平井宏和(著書、分担執筆）
V. 生殖医学 A. 基礎分野での進歩
「最近の知見からみるオキシトシンと母性の新しい概念」
Annual Review 糖尿病・代謝・内分泌. 中外医学社, 196-201, 2009
2008
論文 Articles
Sato T, Torashima T, Sugihara K, Hirai H, Asano M, Yoshioka K.
The scaffold protein JSAP1 regulatesproliferation and differentiation of cerebellar granule cell precursors bymodulating JNK signaling.
Molecular and Cellular Neuroscience 2008 Dec;39(4):569-78. Epub 2008 Aug 30.
Takayama K, Torashima T, Horiuchi H, Hirai H
Purkinje-cell-preferential transduction by lentiviral vectors with the murine stem cell virus promoter.
Neuroscience Letters 2008 Sep 26;443(1):7-11. Epub 2008 Jul 25.
Hirai H.
Progress in transduction of cerebellar Purkinje cells in vivo using viral vectors.
The Cerebellum 2008 7(3):273-8.
Han L, Suda M, Tsuzuki K, Wang R, Ohe Y, Hirai H, Watanabe T, Takeuchi T, Hosaka M.
A large form of secretogranin III functions as a sorting receptor for chromogranin A aggregates in PC12 cells.
Molecular Endocrinology 2008 Aug;22(8):1935-49. Epub 2008 May 15.
Torashima T, Koyama C, Iizuka A, Mitsumura K, Takayama K, Yanagi S, Oue M, Yamaguchi H, Hirai H.
Lentivector-mediated rescue from cerebellar ataxia in a mouse model of spinocerebellar ataxia.
EMBO Reports 2008 Apr;9(4):393-9. Epub 2008 Mar 14.
総説 Review
平井 宏和
脊髄小脳変性症 SCDマウスの運動障害を遺伝子治療で改善
難病と在宅ケア Vol.14 No.2(5月号), 43-46, 2008
2007
論文 Articles
Torashima T, Koyama C, Higashida H, Hirai H.
Production of neuron-preferential lentiviral vectors.
Nature Protocols Epub 2007 Feb 14.
Nakamura K, Hirai H, Torashima T, Miyazaki T, Tsurui H, Xin Y, Ohtsuji M, Shun Lin Q, Tsukamoto K, Nishimura H, Ono M, Watanabe M and Hirose S.
CD3 and immunoglobulin G fc receptor regulate cerebellar functions.
Molecular and Cell Biology 2007 Jul;27(14):5128-34, 2007.
Jin D*, Liu HX*, Hirai H*, Torashima T, Nagai T, Lopatina O, Shnayder NA, Yamada K, Noda M, Seike T, Fujita K, Takasawa S, Yokoyama S, Koizumi K, Shiraishi Y, Tanaka S, Hashii M, Yoshihara T, Higashida K, Islam MS, Yamada N, Hayashi K, Noguchi N, Kato I, Okamoto H, Matsushima A, Salmina A, Munesue T, Shimizu N, Mochida S, Asano M and Higashida H. （*equally contributed)
CD38 is critical for social behaviour by regulating oxytocin secretion.
Nature 2007 Mar 1;446(7131):41-5, 2007.
Kakegawa W, Miyazaki T, Hirai H, Motohashi J, Mishima M, Watanabe M, Yuzaki M.
Ca2+ permeability of the channel pore is not essential for the {delta}2 glutamate receptor to regulate synaptic plasticity and motor coordination.
Journal of Physiology 2007 Mar 15;579(Pt 3):729-35, 2007.
総説 Review
平井 宏和、東田陽博
｢子育て」「他者の認識と記憶」に必要な膜タンパク質ＣＤ38
羊土社・実験医学. Vol.25 No.11(7月号) 1707-1710, 2007
平井 宏和
グルタミン酸受容体リン酸化と運動学習制御
クバプロ・ブレインサイエンス レビュー2007, 123-140
2006
論文 Articles
Hisatsune C, Kuroda Y, Akagi T, Torashima T, Hirai H, Hashikawa T, Inoue T, Mikoshiba K
Inositol 1, 4, 5-Trisphosphate Receptor Type 1 in Granule Cells, not in Purkinje Cells, Regulates the Dendritic Morphology of Purkinje Cells through BDNF Production.
J. Neurosci. 18;26(42):10916-10924, 2006
Torashima T, Yamada N, Itoh M, Yamamoto A, Hirai H.
Exposure of lentiviral vectors to subneutral pH shifts the tropism from Purkinje cell to Bergmann glia.
Eur .J. Neurosci. Jul 24:371-380, 2006
Torashima T, Okoyama S, Nishizaki T, Hirai H.
In vivo transduction of murine cerebellar Purkinje cells by HIV-derived lentiviral vectors.
Brain Res. Apr 12;1082(1):11-22, 2006
Qin Q, Inatome R, Hotta A, Kojima M, Yamamura H, Hirai H, Yoshizawa T, Tanaka H, Fukami K, and Yanagi S.
A novel GTPase, CRAG, mediates PML-associated nuclear body formation and degradation of expanded polyglutamine protein.
J. Cell. Biol. 172:497-504, 2006
Takaturu Y., Takayasu Y., Iino M., Nikkuni O., Ueda Y., Tanaka K.,and Ozawa S.
Roles of glial glutamate transporters in shaping EPSCs at the climbing fiber-Purkinje cell synapses.
Neurosci. Res. 54:140-148, 2006
Takayasu Y., Iino M., Shimamoto K., Tanaka K. and Ozawa S.
Glial glutamate transporters maintain One-to-One relationship at the limbing fiber-Purkinje cell synapse by preventing glutamate spillover
J. Neurosci. 26: 6563-6572., 2006
Tsuzuki K, Tricoire L, Gibelin N, Bourout G, Rossier J, Lambolez B.
Calcium dependence of aequorin bioluminescence dissected by random mutagenesis.
Proc. Natl. Acad. Sci. U.S.A 103: 9500-9505, 2006
総説 Review
平井 宏和
神経細胞選択的なHIV由来レンチウィルスベクターの作製法
羊土社・実験医学 Vol.24 No.19(12月号) 2006, 2997-3001
平井 宏和
小脳シナプス形成とシナプス可塑性を制御する分子・細胞メカニズム
羊土社・実験医学 Vol.24 No.15(増刊) 2006, 192(2402)
